Rung 4 of 7
Animal in vivo
A study in live non-human animals, with a control group, reporting the outcome this claim is about.
Last updated
Qualifies
- Species, strain, group sizes and sex reported.
- A control or sham group.
- Dose reported in mg/kg with the route stated.
- Exposure duration reported.
Does not qualify
- Fewer than three animals per group.
- No control or sham group.
- Dose given only as a total mass with no body weight, so it cannot be scaled or compared.
What this rung does not license you to say
AN ANIMAL DOSE IS NOT A HUMAN DOSE. Allometric scaling to a human-equivalent dose produces a plausible starting point for designing a trial — not a recommendation, and not a safe dose. Rodent healing and regeneration models in particular have a long record of not translating to humans. Where this site shows a human dose range extrapolated from animal data, it says so on the record and it is not a rung 1, 2 or 3 claim.
For example Tendon-to-bone healing in a rat model, treated versus sham, with histological scoring.
Claims currently on this rung
The claim index is generated from the record set and is not built yet.
When it is, this section lists every claim across all 196 records sitting at
animal_in_vivo — which is what makes the ladder auditable rather than decorative.