How we grade
Seven rungs, and the rule that they belong to claims
A compound does not have an evidence level. Each claim about it does — and each one names the rung it sits on, the record behind it, and the reviewer who assigned it.
Last updated
- 1 human RCT Randomised controlled trial in humans. 75 records
- 2 human observational Cohort, case-control, cross-sectional or registry data in humans. 57 records
- 3 human case series Clinician-documented individual human cases, uncontrolled. 2 records
- 4 animal in vivo Whole-animal studies. 36 records
- 5 in vitro Cell culture, tissue, or cell-free systems. 7 records
- 6 theoretical Mechanistic reasoning, with no direct measurement for this claim. none yet
- 7 computational In silico only — docking, structure prediction, QSAR, machine learning. 3 records
The strongest rung, not an average
A claim sits on the highest rung for which at least one record qualifies. Three animal studies do not add up to a human trial, so we never average and never score. The weaker records stay listed underneath, in rung order, so you can see the whole basis.