Tissue Repair & Regeneration

Acetyl Tetrapeptide-5

Last updated 12 August 2026

Evidence on file1 human case report or series · 5 citations not yet graded

Strongest sourceThe Combined Benefits of Definisse™ Revitalise Threads and Definisse [KP1]® Redensifying Cream Treatments: A… (human case report or series)

Manufacturer’s claim vendor marketing

For a proprietary cosmetic ingredient the manufacturer is the originator — there is no upstream to defer to, and this is often the only description that exists. It is reproduced as an attributed claim, with the label its source gave it. It is not graded and it is not evidence — the graded studies are under Literature.

Vendor claims quoted from fetched page: "By day 15, 70% of participants showed a >=30% reduction in puffiness. By day 60, 95% of participants showed improvement."; "Under-eye puffiness volume decreased by up to 29.7% after 28 days"; "Skin elasticity around the eyes increased by 30% over 30 days". Fetched page describes a trial of 20 female volunteers aged 18-65, 0.01% twice daily for 60 days, and a separate trial of 20 females aged 45-60 with "62% reporting medium to very marked improvement".

Manufacturer: Lipotec (acquired by Lubrizol)
Sold as: Eyeseryl
Manufacturer’s recommended use: Vendor claim: "1-10% in skincare products (0.01-0.1% pure peptide)"

Source page — nofollow, because a vendor link is a reference here, not an endorsement.

Dosing on file unverified

0.001-0.01% cream, 1-2x/day (Eyeseryl)

Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.

Literature on file 6

human case series
The Combined Benefits of Definisse™ Revitalise Threads and Definisse [KP1]® Redensifying Cream Treatments: A 19-Patient Case Series. graded on: a case report or series — “Case Series”

Not graded

5 citations whose study design could not be read from the title. Left ungraded rather than guessed at.

Identity

Space-filling 3D model of Acetyl Tetrapeptide-5, carbon grey, nitrogen blue, oxygen red — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

2D chemical structure of Acetyl Tetrapeptide-5 — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

Molecular weight: 492.5
Molecular formula: C20H28N8O7
CAS number: 820959-17-9
PubChem CID: 11620163
InChI key: ROTFCACGLKOUGI-JYJNAYRXSA-N
SMILES: CC(=O)NCCC(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC2=CN=CN2)C(=O)O
InChI: InChI=1S/C20H28N8O7/c1-11(30)23-3-2-17(31)26-14(4-12-6-21-9-24-12)18(32)28-16(8-29)19(33)27-15(20(34)35)5-13-7-22-10-25-13/h6-7,9-10,14-16,29H,2-5,8H2,1H3,(H,21,24)(H,22,25)(H,23,30)(H,26,31)(H,27,33)(H,28,32)(H,34,35)/t14-,15-,16-/m0/s1

Also called

Acetyl Tetrapeptide-5
Eyeseryl

Notes unverified prose

28-60 day studies: under-eye puffiness reduction 32-70%; skin elasticity +35%; manufacturer studies (Lipotec, n~20-30); 28-day study (0.001%, 34-54 yrs); Lipotec Eyeseryl

Not on file 1

1 of the 8 fields we track hold nothing on this record, and each says why. A blank field is a bug; a named absence is a finding.

amino-acid sequencenothing we hold supplies it

Each field links to every other record missing the same thing. The full ledger holds 521 gaps across 136 records.