Tissue Repair & Regeneration

Acetyl Tetrapeptide-9

Last updated 12 August 2026

Evidence on file1 randomised human trial · 1 human observational study · 1 human case report or series · 3 citations not yet graded

Strongest sourceEnhanced Postablative Laser Skin Healing with a Regenerative Skincare Formulation: a Comparative Randomized E… (randomised human trial)

Manufacturer’s claim vendor marketing

For a proprietary cosmetic ingredient the manufacturer is the originator — there is no upstream to defer to, and this is often the only description that exists. It is reproduced as an attributed claim, with the label its source gave it. It is not graded and it is not evidence — the graded studies are under Literature.

Vendor claim (ci.guide): "stimulates the skin's natural regenerative mechanisms"; "skin is thicker and firmer after four months of treatment" (clinical study referenced, n= not stated on fetched page).

Manufacturer: BASF Personal Care (Laboratoires Serobiologiques heritage; per ULProspector listing title and carecreations.basf.us product URL)
Sold as: Dermican (Dermican PW LS 9838 / Dermican LS 9837)

Source page — nofollow, because a vendor link is a reference here, not an endorsement.

Dosing on file unverified

0.9-3% Dermican™ (350 ppm active); 0.1% cream

Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.

Literature on file 6

human observational
An Open-Label Study to Assess the Efficacy and Tolerability of a Multifunctional, 10-Peptide Face and Neck Serum to Address Skin Quality. graded on: indexed as a clinical trial, design not stated — “Clinical Trial”
human RCT
Enhanced Postablative Laser Skin Healing with a Regenerative Skincare Formulation: a Comparative Randomized Evaluator-Blinded Clinical Study. graded on: a randomised study — “Randomized Evaluator-Blinded Clinical Study”
human case series
Real World Case Series: Integrated Skincare With Advanced RGN-6 Serum. graded on: a case report or series — “Case Series”

Not graded

3 citations whose study design could not be read from the title. Left ungraded rather than guessed at.

not graded
MANUFACTURER_DATA_ONLY
not graded
Peptides: Emerging Candidates for the Prevention and Treatment of Skin Senescence: A Review.
not graded
A framework for the safety evaluation of peptides in cosmetics.

Identity

Space-filling 3D model of Acetyl Tetrapeptide-9, carbon grey, nitrogen blue, oxygen red — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

2D chemical structure of Acetyl Tetrapeptide-9 — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

Molecular weight: 539.5
Molecular formula: C22H33N7O9
CAS number: 928006-50-2
PubChem CID: 11606295
InChI key: QNZANUZIBYJBIN-XSWJXKHESA-N
SMILES: CC(C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)N)NC(=O)C
InChI: InChI=1S/C22H33N7O9/c1-10(2)18(21(36)28-15(22(37)38)6-12-8-24-9-25-12)29-20(35)14(7-17(32)33)27-19(34)13(26-11(3)30)4-5-16(23)31/h8-10,13-15,18H,4-7H2,1-3H3,(H2,23,31)(H,24,25)(H,26,30)(H,27,34)(H,28,36)(H,29,35)(H,32,33)(H,37,38)/t13-,14-,15-,18-/m0/s1

Also called

Acetyl Tetrapeptide-9
Dermican

Notes unverified prose

8-week DB RCT (n=17, 45-55): skin elasticity +32%, wrinkle depth -19%; 16-week study: skin thickening & firming; Double-blind controlled study: 32% elasticity, 19% wrinkle reduction at 8 weeks

Not on file 1

1 of the 8 fields we track hold nothing on this record, and each says why. A blank field is a bug; a named absence is a finding.

amino-acid sequencenothing we hold supplies it

Each field links to every other record missing the same thing. The full ledger holds 521 gaps across 136 records.