Cardiovascular & General

Angiotensin (1-7)

Last updated 12 August 2026

Evidence on file1 randomised human trial · 1 citation not yet graded

Strongest sourceNCT04401423: Randomized Controlled Trial of Angiotensin 1-7 (TXA127) for the Treatment of Severe COVID-19 (randomised human trial)

Dosing on file unverified

COVID-19 ICU: start 5 mcg/kg/day → increase to 10 mcg/kg/day after 24h; COVID-19 ICU: start 5 mcg/kg/day → 10 mcg/kg/day; PAD: 1, 2, 4, 8, 12 ng/kg/min escalating; TXA-127: 0.5 mg/kg/day × 5-10 days

Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.

Literature on file 2

human RCT
NCT04401423: Randomized Controlled Trial of Angiotensin 1-7 (TXA127) for the Treatment of Severe COVID-19 graded on: names a randomised controlled trial — “Randomized Controlled”

Not graded

1 citation whose study design could not be read from the title. Left ungraded rather than guessed at.

not graded
Angiotensin (1-7) Induces Mas Receptor Internalization (Hypertension 2011, cited 81x)

Identity

Space-filling 3D model of Angiotensin (1-7), carbon grey, nitrogen blue, oxygen red — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

2D chemical structure of Angiotensin (1-7) — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

Molecular weight: 899.0
Molecular formula: C41H62N12O11
CAS number: 51833-78-4
PubChem CID: 123805
InChI key: PVHLMTREZMEJCG-GDTLVBQBSA-N
SMILES: CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2C(=O)O)NC(=O)[C@H](CC3=CC=C(C=C3)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)N
InChI: InChI=1S/C41H62N12O11/c1-5-22(4)33(38(61)50-29(17-24-19-45-20-47-24)39(62)53-15-7-9-30(53)40(63)64)52-36(59)28(16-23-10-12-25(54)13-11-23)49-37(60)32(21(2)3)51-35(58)27(8-6-14-46-41(43)44)48-34(57)26(42)18-31(55)56/h10-13,19-22,26-30,32-33,54H,5-9,14-18,42H2,1-4H3,(H,45,47)(H,48,57)(H,49,60)(H,50,61)(H,51,58)(H,52,59)(H,55,56)(H,63,64)(H4,43,44,46)/t22-,26-,27-,28-,29-,30-,32-,33-/m0/s1

Notes unverified prose

Phase 1/2; NCT04401423

Not on file 1

1 of the 8 fields we track hold nothing on this record, and each says why. A blank field is a bug; a named absence is a finding.

amino-acid sequencenothing we hold supplies it

Each field links to every other record missing the same thing. The full ledger holds 521 gaps across 136 records.