Cardiovascular & Metabolic

Angiotensin I

Last updated 12 August 2026

Evidence on file1 randomised human trial · 4 human observational studies · 6 citations not yet graded

Strongest sourceNCT06282965: A Randomized, Double-blind, Placebo Controlled Study of the Safety and Efficacy of Angiotensin (… (randomised human trial)

Dosing on file unverified

Research: 3, 10, 30 ng/kg/min infusion; 20 ng/kg/5min incremental; 10 pmol/kg IV bolus

Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.

Literature on file 11

human RCT
NCT06282965: A Randomized, Double-blind, Placebo Controlled Study of the Safety and Efficacy of Angiotensin (1-7) in Persons With Moderate to Severe Traumatic Brain Injury (TBI) graded on: a randomised study — “Randomized, Double-blind, Placebo Controlled Study”
human observational
NCT02646475: Metabolic Effects of Angiotensin-(1-7) graded on: a registered clinical study — “clinicaltrials.gov”
human observational
NCT02245230: Cardiovascular Effects of Angiotensin (1-7) in Essential Hypertension graded on: a registered clinical study — “clinicaltrials.gov”
human observational
NCT03777215: Angiotensin-(1-7) and Energy Expenditure in Human Obesity graded on: a registered clinical study — “clinicaltrials.gov”
human observational
NCT05301192: Angiotensin-(1-7) Cardiovascular Effects in Aging graded on: a registered clinical study — “clinicaltrials.gov”

Not graded

6 citations whose study design could not be read from the title. Left ungraded rather than guessed at.

Identity

Space-filling 3D model of Angiotensin I, carbon grey, nitrogen blue, oxygen red — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

2D chemical structure of Angiotensin I — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

Molecular weight: 1296.5
Molecular formula: C62H89N17O14
CAS number: 9041-90-1
PubChem CID: 3081372
UniProt: P01019 (precursor)
InChI key: ORWYRWWVDCYOMK-HBZPZAIKSA-N
SMILES: CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N[C@@H](CC4=CN=CN4)C(=O)N[C@@H](CC(C)C)C(=O)O)NC(=O)[C@H](CC5=CC=C(C=C5)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)N
InChI: InChI=1S/C62H89N17O14/c1-7-35(6)51(78-56(87)44(25-37-17-19-40(80)20-18-37)74-58(89)50(34(4)5)77-53(84)42(15-11-21-68-62(64)65)71-52(83)41(63)28-49(81)82)59(90)75-46(27-39-30-67-32-70-39)60(91)79-22-12-16-48(79)57(88)73-43(24-36-13-9-8-10-14-36)54(85)72-45(26-38-29-66-31-69-38)55(86)76-47(61(92)93)23-33(2)3/h8-10,13-14,17-20,29-35,41-48,50-51,80H,7,11-12,15-16,21-28,63H2,1-6H3,(H,66,69)(H,67,70)(H,71,83)(H,72,85)(H,73,88)(H,74,89)(H,75,90)(H,76,86)(H,77,84)(H,78,87)(H,81,82)(H,92,93)(H4,64,65,68)/t35-,41-,42-,43-,44-,45-,46-,47-,48-,50-,51-/m0/s1

Notes unverified prose

Human research studies; Human research IV infusions

Not on file 1

1 of the 8 fields we track hold nothing on this record, and each says why. A blank field is a bug; a named absence is a finding.

amino-acid sequencenothing we hold supplies it

Each field links to every other record missing the same thing. The full ledger holds 521 gaps across 136 records.