Tissue Repair & Regeneration

Argireline (Acetyl Hexapeptide-3)

Last updated 12 August 2026

Evidence on file2 human observational studies · 2 citations not yet graded

Strongest sourceNCT01750346: Placebo Controlled Double Blind Study of Acetyl Hexapeptide-8 in Treatment of Blepharospasm (human observational study)

Manufacturer’s claim vendor marketing

For a proprietary cosmetic ingredient the manufacturer is the originator — there is no upstream to defer to, and this is often the only description that exists. It is reproduced as an attributed claim, with the label its source gave it. It is not graded and it is not evidence — the graded studies are under Literature.

Vendor claim (ci.guide): "Botox-like" effect; smoothing action; humectant properties; relaxes facial muscles by destabilizing SNARE complex formation, reducing muscle contraction and attenuating wrinkle formation. No n= or study duration given on fetched page.

Manufacturer: Lipotec SA (now part of Lubrizol)
Sold as: Argireline

Source page — nofollow, because a vendor link is a reference here, not an endorsement.

Dosing on file unverified

10% solution, 2x/day (30 days); 5-10% in serums

Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.

Literature on file 4

human observational
NCT01750346: Placebo Controlled Double Blind Study of Acetyl Hexapeptide-8 in Treatment of Blepharospasm graded on: a registered clinical study — “clinicaltrials.gov”
human observational
NCT01381484: Efficacy and Safety of Topical Argireline in the Treatment of Periorbital Wrinkles graded on: a registered clinical study — “clinicaltrials.gov”

Not graded

2 citations whose study design could not be read from the title. Left ungraded rather than guessed at.

Identity

Space-filling 3D model of Argireline (Acetyl Hexapeptide-3), carbon grey, nitrogen blue, oxygen red — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

2D chemical structure of Argireline (Acetyl Hexapeptide-3) — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

Molecular weight: 887.0
Molecular formula: C35H62N14O11S
CAS number: 616204-22-9
PubChem CID: 71587772
InChI key: AJLNZWYOJAWBCR-OOPVGHQCSA-N
SMILES: CC(=O)N[C@@H](CCC(=O)O)C(=C)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N
InChI: InChI=1S/C35H62N14O11S/c1-18(20(45-19(2)50)9-12-27(52)53)44-23(10-13-28(54)55)31(58)49-25(14-17-61-3)33(60)48-24(8-11-26(36)51)32(59)47-22(7-5-16-43-35(40)41)30(57)46-21(29(37)56)6-4-15-42-34(38)39/h20-25,44H,1,4-17H2,2-3H3,(H2,36,51)(H2,37,56)(H,45,50)(H,46,57)(H,47,59)(H,48,60)(H,49,58)(H,52,53)(H,54,55)(H4,38,39,42)(H4,40,41,43)/t20-,21-,22-,23-,24-,25-/m0/s1

Also called

Acetyl Hexapeptide-8
Argireline

Caveat on these identifiers

Registry record names acetyl hexapeptide-8 (an alternate INCI name for Argireline).

Notes unverified prose

2002 pivotal study: 30% wrinkle reduction (30 days, 10% solution); 17-30% wrinkle depth reduction; NCT01750346; NCT01381484; 2002 pivotal study (30% wrinkle reduction)

Not on file 1

1 of the 8 fields we track hold nothing on this record, and each says why. A blank field is a bug; a named absence is a finding.

amino-acid sequencenothing we hold supplies it

Each field links to every other record missing the same thing. The full ledger holds 521 gaps across 136 records.