Cardiovascular & General; Cardiovascular & Metabolic

Bradykinin

Last updated 12 August 2026

Evidence on file5 human observational studies · 1 human case report or series · 4 citations not yet graded

Strongest sourceNCT00685945: Renin-Angiotensin Aldosterone System and Fibrinolysis(RAAS) Interaction in Humans- Specific Aim 3 (human observational study)

Dosing on file unverified

IV bolus: ~0.1 µg/kg threshold; IV infusion: 0.125-1.25 µg/kg/min; 10-100 pmol/min; IV bolus: 0.001-7.5 µg/kg; Bolus: 60-600 pmol; Infusion: 30-2500 pmol/min

Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.

Literature on file 10

human case series
Pediatric Non-Hereditary, Non-Allergic, Bradykinin-Mediated Angioedema in a Postoperative Intensive Care Patient: A Case Report. graded on: a case report or series — “Case Report”
human observational
NCT00685945: Renin-Angiotensin Aldosterone System and Fibrinolysis(RAAS) Interaction in Humans- Specific Aim 3 graded on: a registered clinical study — “clinicaltrials.gov”
human observational
NCT01413542: Pharmacogenetics of Ace Inhibitor-Associated Angioedema:Aim 1 graded on: a registered clinical study — “clinicaltrials.gov”
human observational
NCT02189122: Comparative Effects of Rapid-Release Aspirin and NHP-544C on Basal and Bradykinin Stimulated Prostacyclin Production graded on: a registered clinical study — “clinicaltrials.gov”
human observational
NCT03738878: Mechanism(s) Underlying Hypotensive Response to ARB/NEP Inhibition - Aim 1 graded on: a registered clinical study — “clinicaltrials.gov”
human observational
NCT01036659: Evaluation of Ecallantide for Acute Treatment of Angiotensin Converting Enzyme Inhibitor Induced Angioedema graded on: a registered clinical study — “clinicaltrials.gov”

Not graded

4 citations whose study design could not be read from the title. Left ungraded rather than guessed at.

Identity

Space-filling 3D model of Bradykinin, carbon grey, nitrogen blue, oxygen red — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

2D chemical structure of Bradykinin — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

Molecular weight: 1060.2
Molecular formula: C50H73N15O11
CAS number: 58-82-2
PubChem CID: 439201 (Bradykinin)
UniProt: P01042 (precursor)
InChI key: QXZGBUJJYSLZLT-FDISYFBBSA-N
SMILES: C1C[C@H](N(C1)C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)N)C(=O)NCC(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N[C@@H](CO)C(=O)N4CCC[C@H]4C(=O)N[C@@H](CC5=CC=CC=C5)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O
InChI: InChI=1S/C50H73N15O11/c51-32(16-7-21-56-49(52)53)45(72)65-25-11-20-39(65)47(74)64-24-9-18-37(64)43(70)58-28-40(67)59-34(26-30-12-3-1-4-13-30)41(68)62-36(29-66)46(73)63-23-10-19-38(63)44(71)61-35(27-31-14-5-2-6-15-31)42(69)60-33(48(75)76)17-8-22-57-50(54)55/h1-6,12-15,32-39,66H,7-11,16-29,51H2,(H,58,70)(H,59,67)(H,60,69)(H,61,71)(H,62,68)(H,75,76)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1

Also called

Bradykinin (Cardiovascular)

Notes unverified prose

Human studies; dose-dependent vasodilation; Human IV/IA studies

Not on file 1

1 of the 8 fields we track hold nothing on this record, and each says why. A blank field is a bug; a named absence is a finding.

amino-acid sequencenothing we hold supplies it

Each field links to every other record missing the same thing. The full ledger holds 521 gaps across 136 records.