Cardiovascular & General; Cardiovascular & Metabolic

Brain Natriuretic Peptide (BNP)

Last updated 12 August 2026

Evidence on file1 randomised human trial · 1 animal study · 1 citation not yet graded

Strongest sourceNCT07617675: Perioperative Recombinant Human Brain Natriuretic Peptide for Renal Protection in Cardiac Surger… (randomised human trial)

Dosing on file unverified

Loading: 1.5-2 µg/kg IV bolus; Maintenance: 0.0075-0.015 µg/kg/min × 48-72h; Loading: 1.5-2 µg/kg IV bolus × 3-15 min; Maintenance: 0.0075-0.015 µg/kg/min continuous × 48-72h; 0.01 µg/kg/min

Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.

Literature on file 3

human RCT
NCT07617675: Perioperative Recombinant Human Brain Natriuretic Peptide for Renal Protection in Cardiac Surgery: the PROTECT-CS Randomized Clinical Trial graded on: names a randomised controlled trial — “Randomized Clinical Trial”
animal in vivo
A new natriuretic peptide in porcine brain (Nature 1988, cited 1337x) graded on: an animal model — “porcine”

Not graded

1 citation whose study design could not be read from the title. Left ungraded rather than guessed at.

not graded
Rapid Measurement of B-Type Natriuretic Peptide in the Emergency Diagnosis of Heart Failure (New England Journal of Medicine 2002, cited 2686x)

Identity

Space-filling 3D model of Brain Natriuretic Peptide (BNP), carbon grey, nitrogen blue, oxygen red — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

2D chemical structure of Brain Natriuretic Peptide (BNP) — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

Molecular weight: 3524.1
Molecular formula: C145H248N50O44S4
PubChem CID: 139211146
UniProt: P16860 (precursor)
InChI key: FJULFJFRGUHITK-UHFFFAOYSA-N
SMILES: CCC(C)C(C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(=O)O)C(=O)NC(CCSC)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC1=CNC=N1)C(=O)O)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(CO)NC(=O)CNC(=O)C(CC(C)C)NC(=O)CNC(=O)C2CSSCC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)N2)CCCNC(=N)N)CC3=CC=CC=C3)NC(=O)CNC(=O)C(CO)NC(=O)CNC(=O)C(CCC(=O)N)NC(=O)C(C(C)C)NC(=O)C(CCSC)NC(=O)C(CCCCN)NC(=O)C4CCCN4C(=O)C(CO)N.CC(=O)O
InChI: InChI=1S/C143H244N50O42S4.C2H4O2/c1-13-76(10)112(137(232)180-86(36-26-48-161-143(155)156)122(217)183-93(56-109(206)207)128(223)178-88(40-50-236-11)124(219)173-81(30-17-20-42-144)119(214)174-83(32-19-22-44-146)125(220)190-111(75(8)9)136(231)184-91(53-73(4)5)127(222)176-84(34-24-46-159-141(151)152)121(216)175-85(35-25-47-160-142(153)154)123(218)185-94(139(234)235)55-78-57-157-71-167-78)192-132(227)99(68-199)188-131(226)98(67-198)187-130(225)97(66-197)186-129(224)96(65-196)171-107(204)61-163-114(209)90(52-72(2)3)169-105(202)59-166-117(212)100-69-238-239-70-101(133(228)182-92(54-77-28-15-14-16-29-77)115(210)164-58-104(201)168-80(118(213)189-100)33-23-45-158-140(149)150)172-108(205)62-165-116(211)95(64-195)170-106(203)60-162-113(208)87(38-39-103(148)200)181-135(230)110(74(6)7)191-126(221)89(41-51-237-12)177-120(215)82(31-18-21-43-145)179-134(229)102-37-27-49-193(102)138(233)79(147)63-194;1-2(3)4/h14-16,28-29,57,71-76,79-102,110-112,194-199H,13,17-27,30-56,58-70,144-147H2,1-12H3,(H2,148,200)(H,157,167)(H,162,208)(H,163,209)(H,164,210)(H,165,211)(H,166,212)(H,168,201)(H,169,202)(H,170,203)(H,171,204)(H,172,205)(H,173,219)(H,174,214)(H,175,216)(H,176,222)(H,177,215)(H,178,223)(H,179,229)(H,180,232)(H,181,230)(H,182,228)(H,183,217)(H,184,231)(H,185,218)(H,186,224)(H,187,225)(H,188,226)(H,189,213)(H,190,220)(H,191,221)(H,192,227)(H,206,207)(H,234,235)(H4,149,150,158)(H4,151,152,159)(H4,153,154,160)(H4,155,156,161);1H3,(H,3,4)

Also called

BNP (Brain Natriuretic Peptide)

Caveat on these identifiers

NCT07617675 studies recombinant human BNP, not ANP.

Notes unverified prose

NCT07617675; NCT07617675 (0.01 µg/kg/min)

Not on file 2

2 of the 8 fields we track hold nothing on this record, and each says why. A blank field is a bug; a named absence is a finding.

CAS registry numbernothing we hold supplies it
amino-acid sequencenothing we hold supplies it

Each field links to every other record missing the same thing. The full ledger holds 521 gaps across 136 records.