Cardiovascular & General; Cardiovascular & Metabolic

C-Type Natriuretic Peptide (CNP)

Last updated 12 August 2026

Evidence on file3 human observational studies · 3 animal studies · 2 citations not yet graded

Strongest sourceAchondroplasia management in the era of targeted therapies: a meta-analysis of C-type natriuretic peptide ana… (human observational study)

Dosing on file unverified

10 pmol/kg/min infusion; 0.43 nmol/kg single dose (Phase I/II research); 0.43 nmol/kg single dose; Phase I/II research only

Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.

Literature on file 8

human observational
Achondroplasia management in the era of targeted therapies: a meta-analysis of C-type natriuretic peptide analogs. graded on: a synthesis of human studies — “meta-analysis”
animal in vivo
Combined treatment with a C-type natriuretic peptide analog and bisphosphonate enhances bone growth in growing mice with osteogenesis imperfecta: a pilot study. graded on: an animal model — “mice”
animal in vivo
Supplementation with C-type natriuretic peptide during pre-in vitro maturation regulates key aspects of cumulus cell physiology in cattle. graded on: an animal model — “cattle”
animal in vivo
C-type natriuretic peptide pre-maturation culture affects cytoplasmic maturation in bovine oocytes†. graded on: an animal model — “bovine”
human observational
NCT01075776: The Effects of C-type Natriuretic Peptide on Endothelial Function Following Ischaemia-Reperfusion in the Human Forearm graded on: a registered clinical study — “clinicaltrials.gov”
human observational
NCT04006171: C Type Natriuretic Peptide and Polycystic Ovary Syndrome graded on: a registered clinical study — “clinicaltrials.gov”

Not graded

2 citations whose study design could not be read from the title. Left ungraded rather than guessed at.

Identity

Space-filling 3D model of C-Type Natriuretic Peptide (CNP), carbon grey, nitrogen blue, oxygen red — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

2D chemical structure of C-Type Natriuretic Peptide (CNP) — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

Molecular weight: 2197.6
Molecular formula: C93H157N27O28S3
CAS number: 127869-51-6
PubChem CID: 16179407
UniProt: P23582 (precursor)
InChI key: UHSBKBYWHCBDCJ-DYGWFTAGSA-N
SMILES: CC[C@H](C)[C@H]1C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CCCNC(=N)N)CC(=O)O)CC(C)C)CCCCN)CC(C)C)CC2=CC=CC=C2)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)CN)C(=O)O)CC(C)C)CO)CCSC)CO
InChI: InChI=1S/C93H157N27O28S3/c1-12-52(10)76-91(146)104-42-72(127)108-65(44-122)88(143)114-57(26-30-149-11)82(137)118-64(43-121)80(135)103-39-70(125)106-58(31-48(2)3)78(133)101-41-74(129)110-68(92(147)148)47-151-150-46-67(109-73(128)40-100-77(132)54(23-16-18-27-94)111-89(144)66(45-123)119-85(140)59(32-49(4)5)105-69(124)37-96)90(145)116-62(35-53-21-14-13-15-22-53)79(134)102-38-71(126)107-60(33-50(6)7)84(139)112-55(24-17-19-28-95)81(136)115-61(34-51(8)9)86(141)117-63(36-75(130)131)87(142)113-56(83(138)120-76)25-20-29-99-93(97)98/h13-15,21-22,48-52,54-68,76,121-123H,12,16-20,23-47,94-96H2,1-11H3,(H,100,132)(H,101,133)(H,102,134)(H,103,135)(H,104,146)(H,105,124)(H,106,125)(H,107,126)(H,108,127)(H,109,128)(H,110,129)(H,111,144)(H,112,139)(H,113,142)(H,114,143)(H,115,136)(H,116,145)(H,117,141)(H,118,137)(H,119,140)(H,120,138)(H,130,131)(H,147,148)(H4,97,98,99)/t52-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,76-/m0/s1

Also called

CNP (C-Type Natriuretic Peptide)

Notes unverified prose

Human studies:; Human IV infusion studies

Not on file 1

1 of the 8 fields we track hold nothing on this record, and each says why. A blank field is a bug; a named absence is a finding.

amino-acid sequencenothing we hold supplies it

Each field links to every other record missing the same thing. The full ledger holds 521 gaps across 136 records.