Hormonal & Sexual Health

Cetrorelix

Last updated 12 August 2026

Evidence on fileFDA-approved · 1 randomised human trial · 1 citation not yet graded

Strongest sourceOvarian stimulation with HMG: results of a prospective randomized phase III European study comparing the lute… (randomised human trial)

Regulatory status

Approved by the FDA. Marketed as CETROTIDE, CETRORELIX ACETATE. Earliest approval 2000-08-11. Application NDA021197, ANDA214540, ANDA217776, ANDA218150.

An approval grades as rung 1 on this site, because 21 CFR 314.126 requires adequate and well-controlled human investigations and one cannot be granted without them. It covers specific indications and doses, though, and does not transfer to other uses of the same molecule.

Dosing on file unverified

0.25 mg SC QD starting day 5-6 of stimulation until hCG day; 3 mg single dose also available

Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.

Literature on file 3

human RCT
Ovarian stimulation with HMG: results of a prospective randomized phase III European study comparing the luteinizing hormone-releasing hormone (LHRH)-antagonist cetrorelix and the LHRH-agonist buserelin (Human Reproduction 2000, cited 252x) graded on: a randomised study — “randomized phase III European study”
human RCT
FDA approval NDA021197, ANDA214540, ANDA217776, ANDA218150 graded on: an FDA approval (NDA021197, ANDA214540, ANDA217776, ANDA218150), which requires adequate and well-controlled human investigations — “NDA021197, ANDA214540, ANDA217776, ANDA218150”

Not graded

1 citation whose study design could not be read from the title. Left ungraded rather than guessed at.

not graded
Suppression of the endogenous luteinizing hormone surge by the gonadotrophin-releasing hormone antagonist Cetrorelix during ovarian stimulation (Human Reproduction 1994, cited 239x)

Identity

Space-filling 3D model of Cetrorelix, carbon grey, nitrogen blue, oxygen red — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

2D chemical structure of Cetrorelix — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

Molecular weight: 1431.0
Molecular formula: C70H92ClN17O14
CAS number: 120287-85-6
PubChem CID: 25074887
InChI key: SBNPWPIBESPSIF-MHWMIDJBSA-N
Sequence: XXXSYXLRPA
SMILES: C[C@H](C(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCCNC(=O)N)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC3=CN=CC=C3)NC(=O)[C@@H](CC4=CC=C(C=C4)Cl)NC(=O)[C@@H](CC5=CC6=CC=CC=C6C=C5)NC(=O)C
InChI: InChI=1S/C70H92ClN17O14/c1-39(2)31-52(61(94)82-51(15-9-28-77-69(73)74)68(101)88-30-10-16-58(88)67(100)79-40(3)59(72)92)83-60(93)50(14-8-29-78-70(75)102)81-63(96)54(34-43-20-25-49(91)26-21-43)86-66(99)57(38-89)87-65(98)56(36-45-11-7-27-76-37-45)85-64(97)55(33-42-18-23-48(71)24-19-42)84-62(95)53(80-41(4)90)35-44-17-22-46-12-5-6-13-47(46)32-44/h5-7,11-13,17-27,32,37,39-40,50-58,89,91H,8-10,14-16,28-31,33-36,38H2,1-4H3,(H2,72,92)(H,79,100)(H,80,90)(H,81,96)(H,82,94)(H,83,93)(H,84,95)(H,85,97)(H,86,99)(H,87,98)(H4,73,74,77)(H3,75,78,102)/t40-,50-,51+,52+,53-,54+,55-,56-,57+,58+/m1/s1

Notes unverified prose

FDA-approved (Cetrotide); DailyMed; Drugs.com

Not on file 0

All 8 tracked fields hold a value on this record: molecular weight and formula, CAS number, PubChem CID, amino-acid sequence, SMILES, InChI and InChI key.

Counted from the record itself, not from what a source said it was missing. 136 of 185 records still have at least one empty.