Tissue Repair & Regeneration

Dipeptide Diaminobutyroyl Benzylamide Diacetate

Last updated 12 August 2026

Evidence on file1 human observational study · 1 in-vitro study · 4 citations not yet graded

Strongest sourceAn Open-Label Study to Assess the Efficacy and Tolerability of a Multifunctional, 10-Peptide Face and Neck Se… (human observational study)

Manufacturer’s claim vendor marketing

For a proprietary cosmetic ingredient the manufacturer is the originator — there is no upstream to defer to, and this is often the only description that exists. It is reproduced as an attributed claim, with the label its source gave it. It is not graded and it is not evidence — the graded studies are under Literature.

Vendor claim quoted from incidecoder (citing manufacturer studies): "4% Syn-Ake used for 28 days resulted in 21% smoother and 15-20% less wrinkled skin with max values up to 52%." Smoothing observable on 80% of volunteers; wrinkle reduction evident on 73%.

Manufacturer: Not confirmed on fetched pages (Pentapharm/DSM hypothesis not verified; SpecialChem lists only resellers: BrightGene Health 'Peptixel SYN-AKE', Uniproma blends)
Sold as: Syn-Ake
Manufacturer’s recommended use: 4% (per incidecoder, citing manufacturer studies)

Source page — nofollow, because a vendor link is a reference here, not an endorsement.

Dosing on file unverified

4% cream, 2x/day (SYN-AKE)

Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.

Literature on file 6

human observational
An Open-Label Study to Assess the Efficacy and Tolerability of a Multifunctional, 10-Peptide Face and Neck Serum to Address Skin Quality. graded on: indexed as a clinical trial, design not stated — “Clinical Trial”
in vitro
In vitro, ex vivo, instrumental and clinical evaluation of a topical cream on the signs of periorbital ageing. graded on: an in-vitro system — “In vitro”

Not graded

4 citations whose study design could not be read from the title. Left ungraded rather than guessed at.

Identity

Space-filling 3D model of Dipeptide Diaminobutyroyl Benzylamide Diacetate, carbon grey, nitrogen blue, oxygen red — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

2D chemical structure of Dipeptide Diaminobutyroyl Benzylamide Diacetate — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

Molecular weight: 495.6
Molecular formula: C23H37N5O7
CAS number: 823202-99-9
PubChem CID: 71465152
InChI key: HSUGRPOJOBRRBK-SXBSVMRRSA-N
SMILES: CC(=O)O.CC(=O)O.C1C[C@H](N(C1)C(=O)CCN)C(=O)N[C@@H](CCN)C(=O)NCC2=CC=CC=C2
InChI: InChI=1S/C19H29N5O3.2C2H4O2/c20-10-8-15(18(26)22-13-14-5-2-1-3-6-14)23-19(27)16-7-4-12-24(16)17(25)9-11-21;2*1-2(3)4/h1-3,5-6,15-16H,4,7-13,20-21H2,(H,22,26)(H,23,27);2*1H3,(H,3,4)/t15-,16-;;/m0../s1

Also called

Syn-Ake

Notes unverified prose

28-day study (n=45, 4%): 50% wrinkle depth reduction; 28-day study (n=15, 4%): 52% wrinkle reduction; Clinical study (n=45, 4%, 28 days): 50% wrinkle reduction

Not on file 1

1 of the 8 fields we track hold nothing on this record, and each says why. A blank field is a bug; a named absence is a finding.

amino-acid sequencenothing we hold supplies it

Each field links to every other record missing the same thing. The full ledger holds 521 gaps across 136 records.