PEPTIDE CORPUS

Cognitive & Neuroprotection

β-Endorphin

Last updated

Evidence on file2 human observational studies · 1 animal study · 3 citations not yet graded
Strongest sourceA Systematic Review With Meta-Analysis of Endogenous Opioid System Biomarkers in Patients With Chronic Axial… (human observational study)

Dosing on file unverified

1.5-11.5 mg IV; 6-440 µg/kg IV infusion; 1.5-10 mg IV over 5-35 min

Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.

Literature on file 6

Not graded

3 citations whose study design could not be read from the title. Left ungraded rather than guessed at.

Identity

UniProt
P01213 (precursor)

Caveat on these identifiers

P01213 (prodynorphin) is correct for Dynorphin A only; beta-endorphin derives from POMC, not this precursor.

Notes unverified prose

1977-1999 human studies: 1.5-11.5 mg IV; 440 µg/kg/30 min infusion produced no toxicity; Historical human IV infusion studies (1970s-1990s)

Not on file 8

8 of the 8 fields we track hold nothing on this record, and each says why. A blank field is a bug; a named absence is a finding.

Each field links to every other record missing the same thing. The full ledger holds 521 gaps across 136 records.