Longevity & Cellular Health; Sleep, Mood & Stress; Cognitive & Neuroprotection

Epitalon

A circadian and longevity-oriented peptide signal.

Last updated 12 August 2026

Studied forSleep quality · Circadian rhythm · Stress resilience

Evidence on file1 in-vitro study · 6 citations not yet graded

Strongest sourceThe Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinop… (in-vitro study)

Mechanism

Associated with telomere, clock-gene, and melatonin modulation.

Reported effects

What sources associate with this compound. Reported categories, not outcomes we have graded — each would need its own citation and rung.

Sleep quality
Circadian rhythm
Stress resilience

Dosing on file unverified

5-10 mg daily, cycled 1.5–3 weeks

Reported dose	Volume	Draw
Low — 5 mg	1 mL	100 units
High — 10 mg	2 mL	200 units

What that assumes. Assumes 10 mg in 2 mL (5000 mcg/mL) drawn on a U-100 barrel — the preset on this record, not a recommendation and not the only way to mix it. Change the vial mass, the diluent or the barrel and every number in this table changes. Run your own.

Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.

Reconstitution

Vial	Diluent	Concentration	Typical dose	Draw
10 mg	2 mL	5000 mcg/mL	5000 mcg	100 units

mass ÷ diluent = concentration; dose ÷ concentration = volume; volume × the syringe factor = units on the barrel (100 for U-100, 40 for U-40). Run your own numbers.

Literature on file 7

in vitro
The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy. graded on: an in-vitro system — “in Vitro”

Not graded

6 citations whose study design could not be read from the title. Left ungraded rather than guessed at.

Identity

Space-filling 3D model of Epitalon, carbon grey, nitrogen blue, oxygen red — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

2D chemical structure of Epitalon — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

Molecular weight: 390.35
Molecular formula: C14H22N4O9
CAS number: 307297-39-8
PubChem CID: 219042
InChI key: HGHOBRRUMWJWCU-FXQIFTODSA-N
Sequence: AEDG
SMILES: C[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)O)N
InChI: InChI=1S/C14H22N4O9/c1-6(15)12(25)17-7(2-3-9(19)20)14(27)18-8(4-10(21)22)13(26)16-5-11(23)24/h6-8H,2-5,15H2,1H3,(H,16,26)(H,17,25)(H,18,27)(H,19,20)(H,21,22)(H,23,24)/t6-,7-,8-/m0/s1

Classified as

Subcutaneousroute: This is the route the reconstitution arithmetic assumes. Mass divided by diluent volume gives concentration, dose divided by concentration gives volume, and volume in mL multiplied by 100 gives units on a U-100 barrel: 5 mg in 2 mL is 2.5 mg/mL, and 0.25 mg comes out at 0.1 mL, which is 10 units.

Also called

DTXCID801381023
DTXSID80952957
Epitalon
Epitalon (Longevity)
Epitalon (Sleep)
alanyl-glutamyl-aspartyl-glycine
epithalone

Caveat on these identifiers

Source files disagreed on evidence tier for this peptide.

Notes unverified prose

No registered human clinical trials exist; 5-10 mg/day derived from Khavinson et al. non-RCT studies; No FDA approval; no official dosing guideline; Russian protocols based on Khavinson et al.; Human observational studies by Khavinson et al.; No Western Phase 2/3 RCTs; standard protocol derived from Russian small studies; Human observational (Khavinson); Same as longevity (Khavinson observational)

Not on file 0

All 8 tracked fields hold a value on this record: molecular weight and formula, CAS number, PubChem CID, amino-acid sequence, SMILES, InChI and InChI key.

Counted from the record itself, not from what a source said it was missing. 136 of 185 records still have at least one empty.

Listed prices 2

What 2 shops we track listed for Epitalon, read from their own public catalogues on 2026-08-12. We take no commission on these and they are not ranked by any payment — how vendors are scored.

Listed in CAD
Vendor	Size	Price	Per mg
Amino Peptides	20 mg	$54.99 CAD	$2.75/mg
NCRP Canada	size not listed	$39.00 CAD	—

Prices are the vendor's own listing, reproduced with the date we read it — never converted between currencies, and compared per milligram only where the vendor states the vial size.