Tissue Repair & Regeneration

GHK (Glycyl-L-Histidyl-L-Lysine)

Last updated 12 August 2026

Evidence on file2 human observational studies · 1 animal study · 4 citations not yet graded

Strongest sourceA gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK. (human observational study)

Manufacturer’s claim vendor marketing

For a proprietary cosmetic ingredient the manufacturer is the originator — there is no upstream to defer to, and this is often the only description that exists. It is reproduced as an attributed claim, with the label its source gave it. It is not graded and it is not evidence — the graded studies are under Literature.

Vendor claims quoted from incidecoder (citing the Kollaren manufacturer): stimulates "collagen but also other essential skin proteins such as fibronectin, elastin, and laminin"; "boost tissue repair and thus help acne scars to heal faster". Creative Peptides page: "can increase the firmness of the skin by activating the extracellular matrix proteins synthesis". No n= or duration given.

Manufacturer: Not confirmed on fetched pages (incidecoder cites 'manufacturer' claims for Kollaren but does not name the company)
Sold as: Kollaren
Manufacturer’s recommended use: Not specified on fetched pages

Source page — nofollow, because a vendor link is a reference here, not an endorsement.

Dosing on file unverified

Topical: varies by formulation; Oral: combination therapy

Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.

Literature on file 7

human observational
A gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK. graded on: an observational human design — read from the indexed abstract — “cross-sectional”
animal in vivo
A therapeutic approach for diabetic wound healing using biotinylated GHK incorporated collagen matrices. graded on: an animal model — read from the indexed abstract — “Cattle”
human observational
Topical GHK-Cu Gel for Acute Skin Wound Healing graded on: a registered clinical study — “clinicaltrials.gov”

Not graded

4 citations whose study design could not be read from the title. Left ungraded rather than guessed at.

Identity

Space-filling 3D model of GHK (Glycyl-L-Histidyl-L-Lysine), carbon grey, nitrogen blue, oxygen red — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

2D chemical structure of GHK (Glycyl-L-Histidyl-L-Lysine) — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

Molecular weight: 340.38
Molecular formula: C14H24N6O4
CAS number: 49557-75-7
PubChem CID: 73587
InChI key: MVORZMQFXBLMHM-QWRGUYRKSA-N
SMILES: C1=C(NC=N1)C[C@@H](C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)CN
InChI: InChI=1S/C14H24N6O4/c15-4-2-1-3-10(14(23)24)20-13(22)11(19-12(21)6-16)5-9-7-17-8-18-9/h7-8,10-11H,1-6,15-16H2,(H,17,18)(H,19,21)(H,20,22)(H,23,24)/t10-,11-/m0/s1

Also called

Kollaren
Tripeptide-1

Notes unverified prose

Open-label trial (n=48, 3 months): biotinyl tripeptide-1 for androgenetic alopecia; RCT for skin aging; wound healing studies; Open-label trial (n=48, 3 months) for androgenetic alopecia

Not on file 1

1 of the 8 fields we track hold nothing on this record, and each says why. A blank field is a bug; a named absence is a finding.

amino-acid sequencenothing we hold supplies it

Each field links to every other record missing the same thing. The full ledger holds 521 gaps across 136 records.

Listed prices 2

What 1 shop we track listed for GHK (Glycyl-L-Histidyl-L-Lysine), read from their own public catalogues on 2026-08-12. We take no commission on these and they are not ranked by any payment — how vendors are scored.

Listed in CAD
Vendor	Size	Price	Per mg
Canada Peptide	size not listed	$49.99 CAD	—
Canada Peptide	size not listed	$49.99 CAD	—

Prices are the vendor's own listing, reproduced with the date we read it — never converted between currencies, and compared per milligram only where the vendor states the vial size.