Growth Hormone & Performance

GHRH (Growth Hormone-Releasing Hormone)

Last updated 12 August 2026

Evidence on file1 human observational study · 1 animal study · 1 citation not yet graded

Strongest sourceNCT00791843: The Effect of GHRH Therapy on Myocardial Structure and Function in Congestive Heart Failure (human observational study)

Dosing on file unverified

SC: 10 mcg/kg nightly; 0.5-1.0 mg BID; 2 mg QD; IV: 1 mcg/kg q3h; 0.03-3.0 mcg/kg

Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.

Literature on file 3

human observational
NCT00791843: The Effect of GHRH Therapy on Myocardial Structure and Function in Congestive Heart Failure graded on: a registered clinical study — “clinicaltrials.gov”
animal in vivo
GHRH receptor of little mice contains a missense mutation in the extracellular domain that disrupts receptor function (Nature Genetics 1993, cited 312x) graded on: an animal model — “mice”

Not graded

1 citation whose study design could not be read from the title. Left ungraded rather than guessed at.

not graded
GHRH and sleep (Sleep Medicine Reviews 2004, cited 145x)

Identity

Space-filling 3D model of GHRH (Growth Hormone-Releasing Hormone), carbon grey, nitrogen blue, oxygen red — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

2D chemical structure of GHRH (Growth Hormone-Releasing Hormone) — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

Molecular weight: 3538.0
Molecular formula: C155H258N44O48S
PubChem CID: 172966663
UniProt: P01286 (precursor)
InChI key: MTFNBFPHFHTPSL-AQAMGABZSA-N
Sequence: YADAIFTNSYRKVLGQLSARKLLQDIMSR
SMILES: CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CC3=CC=C(C=C3)O)N.CC(=O)O.CC(=O)O.CC(=O)O
InChI: InChI=1S/C149H246N44O42S.3C2H4O2/c1-20-77(13)116(191-122(211)81(17)168-132(221)104(66-113(204)205)178-121(210)79(15)167-123(212)88(152)62-84-39-43-86(198)44-40-84)145(234)185-102(63-83-32-23-22-24-33-83)138(227)193-118(82(18)197)146(235)186-103(65-111(155)202)137(226)189-108(71-196)142(231)182-101(64-85-41-45-87(199)46-42-85)136(225)175-93(38-31-56-165-149(161)162)126(215)174-91(35-26-28-53-151)131(220)190-115(76(11)12)143(232)184-97(58-72(3)4)124(213)166-68-112(203)170-94(47-49-109(153)200)128(217)180-100(61-75(9)10)135(224)188-106(69-194)140(229)169-80(16)120(209)172-92(37-30-55-164-148(159)160)125(214)173-90(34-25-27-52-150)127(216)179-99(60-74(7)8)134(223)181-98(59-73(5)6)133(222)176-95(48-50-110(154)201)129(218)183-105(67-114(206)207)139(228)192-117(78(14)21-2)144(233)177-96(51-57-236-19)130(219)187-107(70-195)141(230)171-89(119(156)208)36-29-54-163-147(157)158;3*1-2(3)4/h22-24,32-33,39-46,72-82,88-108,115-118,194-199H,20-21,25-31,34-38,47-71,150-152H2,1-19H3,(H2,153,200)(H2,154,201)(H2,155,202)(H2,156,208)(H,166,213)(H,167,212)(H,168,221)(H,169,229)(H,170,203)(H,171,230)(H,172,209)(H,173,214)(H,174,215)(H,175,225)(H,176,222)(H,177,233)(H,178,210)(H,179,216)(H,180,217)(H,181,223)(H,182,231)(H,183,218)(H,184,232)(H,185,234)(H,186,235)(H,187,219)(H,188,224)(H,189,226)(H,190,220)(H,191,211)(H,192,228)(H,193,227)(H,204,205)(H,206,207)(H4,157,158,163)(H4,159,160,164)(H4,161,162,165);3*1H3,(H,3,4)/t77-,78-,79-,80-,81-,82+,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,115-,116-,117-,118-;;;/m0.../s1

Also called

GHRH (Growth Hormone Releasing Hormone)

Notes unverified prose

Human trials: 10 mcg/kg SC; 0.5-1.0 mg SC BID; 2 mg SC QD; IV 1 mcg/kg; Human SC/IV trials; NCT00791843 (heart failure); 2 mg SC

Not on file 1

1 of the 8 fields we track hold nothing on this record, and each says why. A blank field is a bug; a named absence is a finding.

CAS registry numbernothing we hold supplies it

Each field links to every other record missing the same thing. The full ledger holds 521 gaps across 136 records.