Hormonal & Sexual Health

GnRH (Gonadotropin-Releasing Hormone)

Last updated 12 August 2026

Evidence on file1 randomised human trial · 4 human observational studies · 1 animal study · 4 citations not yet graded

Strongest sourceNCT04037254: Randomized Phase II Trial of Niraparib With Standard Combination Radiotherapy and Androgen Depri… (randomised human trial)

Dosing on file unverified

100 mcg IV/SC single dose (diagnostic); 5 mcg q90min (range 1-20 mcg) by pulsatile pump × 21 days

Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.

Literature on file 10

animal in vivo
Single-nuclei RNA sequencing reveals heterogeneity within developing GnRH3 neurons in zebrafish. graded on: an animal model — “zebrafish”
human observational
NCT00586898: Rapid Hormonal Cycling as Treatment for Patients With Prostate Cancer: The Men's Cycle graded on: a registered clinical study — “clinicaltrials.gov”
human observational
NCT00587431: Docetaxel With Rapid Hormonal Cycling as a Treatment for Patients With Prostate Cancer graded on: a registered clinical study — “clinicaltrials.gov”
human observational
NCT02956447: Administration of Kisspeptin in Patients With Hyperprolactinemia graded on: a registered clinical study — “clinicaltrials.gov”
human RCT
NCT04037254: Randomized Phase II Trial of Niraparib With Standard Combination Radiotherapy and Androgen Deprivation Therapy (ADT) in High Risk Prostate Cancer (With Initial Phase I) (NADIR*) *Randomized Phase II Trial of Niraparib With Standard Combination Androgen DeprIvation Therapy (ADT) and Radiotherapy in High Risk Prostate Cancer (With Initial Phase I) graded on: a randomised trial — “Randomized Phase II Trial”
human observational
NCT01381016: Estrogen Sensitivity and Ovulatory Dysfunction in Obesity graded on: a registered clinical study — “clinicaltrials.gov”

Not graded

4 citations whose study design could not be read from the title. Left ungraded rather than guessed at.

Identity

Space-filling 3D model of GnRH (Gonadotropin-Releasing Hormone), carbon grey, nitrogen blue, oxygen red — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

2D chemical structure of GnRH (Gonadotropin-Releasing Hormone) — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

Molecular weight: 1212.3
Molecular formula: C60H73N15O13
PubChem CID: 16132914
UniProt: P01148 (precursor)
InChI key: NMJREATYWWNIKX-UHFFFAOYSA-N
Sequence: XHWSYGWLPG
SMILES: CC(C)CC(C(=O)N1CCCC1C(=O)NCC(=O)N)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)CNC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CO)NC(=O)C(CC5=CNC6=CC=CC=C65)NC(=O)C(CC7=CN=CN7)NC(=O)C8CCC(=O)N8
InChI: InChI=1S/C60H73N15O13/c1-32(2)20-47(60(88)75-19-7-12-49(75)59(87)65-28-50(61)78)73-55(83)44(22-34-25-63-40-10-5-3-8-38(34)40)69-52(80)29-66-53(81)43(21-33-13-15-37(77)16-14-33)70-58(86)48(30-76)74-56(84)45(23-35-26-64-41-11-6-4-9-39(35)41)71-57(85)46(24-36-27-62-31-67-36)72-54(82)42-17-18-51(79)68-42/h3-6,8-11,13-16,25-27,31-32,42-49,63-64,76-77H,7,12,17-24,28-30H2,1-2H3,(H2,61,78)(H,62,67)(H,65,87)(H,66,81)(H,68,79)(H,69,80)(H,70,86)(H,71,85)(H,72,82)(H,73,83)(H,74,84)

Notes unverified prose

Fertility protocols; Lutrepulse

Not on file 1

1 of the 8 fields we track hold nothing on this record, and each says why. A blank field is a bug; a named absence is a finding.

CAS registry numbernothing we hold supplies it

Each field links to every other record missing the same thing. The full ledger holds 521 gaps across 136 records.