Gonadorelin

Literature on file 11

• animal in vivo
  Recombinant bovine somatotropin at synchronization initiation, but not at embryo transfer, enhances fertility in embryo-recipient heifers: Associations with follicular, luteal, and embryonic outcomes. graded on: an animal model — “bovine”
• human RCT
  NCT01976728: A Multicenter, Double-Blind, Randomized, Placebo-Controlled Study Evaluating Three Doses of Subcutaneous Pulsatile GnRH Administered Via OmniPod Pump for Ovulation Induction in Female Subjects With Primary Amenorrhea With Hypogonadotropic Hypogonadism graded on: a randomised study — “Randomized, Placebo-Controlled Study”
• human RCT
  NCT04037254: Randomized Phase II Trial of Niraparib With Standard Combination Radiotherapy and Androgen Deprivation Therapy (ADT) in High Risk Prostate Cancer (With Initial Phase I) (NADIR*) *Randomized Phase II Trial of Niraparib With Standard Combination Androgen DeprIvation Therapy (ADT) and Radiotherapy in High Risk Prostate Cancer (With Initial Phase I) graded on: a randomised trial — “Randomized Phase II Trial”
• human observational
  NCT01381016: Estrogen Sensitivity and Ovulatory Dysfunction in Obesity graded on: a registered clinical study — “clinicaltrials.gov”
• human observational
  NCT01457703: Reproductive Hormonal Alterations in Obesity, AIMS #1 & #2 graded on: a registered clinical study — “clinicaltrials.gov”
• human RCT
  NCT04390646: Effect of Pulsatile GnRH Therapy on Cognition in Down Syndrome: Randomized Placebo Control Study graded on: a randomised study — “Randomized Placebo Control Study”

Not graded

5 citations whose study design could not be read from the title. Left ungraded rather than guessed at.

• not graded
  Gonadorelin (1988)
• not graded
  Estradiol treatment and double dose of GnRH for resynchronization protocols and timed artificial insemination in lactating dairy cows.
• not graded
  The neuroendocrine basis for parental care in teleost fish.
• not graded
  Diagnostic Usefulness of Subcutaneous Triptorelin Stimulation Testing in the Evaluation of Central Precocious Puberty in Girls.
• not graded
  Increasing gonadorelin hydrochloride dose at the first GnRH of breeding Ovsynch enhances luteinizing hormone release, ovulatory response, and pregnancy in first-service lactating dairy cows.

Identity

PubChem CID 638793 computed 3D conformer

Skeletal formulathe canonical depiction

Drawn by PubChem from CID 638793, the identifier on this record.

Molecular weight

1182.3

Molecular formula

C55H75N17O13

CAS number

33515-09-2

PubChem CID

638793

InChI key

XLXSAKCOAKORKW-AQJXLSMYSA-N

Sequence

XHWSYGLRPG

SMILES

CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N)NC(=O)CNC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CC5=CN=CN5)NC(=O)[C@@H]6CCC(=O)N6

InChI

InChI=1S/C55H75N17O13/c1-29(2)19-38(49(80)67-37(9-5-17-60-55(57)58)54(85)72-18-6-10-43(72)53(84)62-25-44(56)75)66-46(77)26-63-47(78)39(20-30-11-13-33(74)14-12-30)68-52(83)42(27-73)71-50(81)40(21-31-23-61-35-8-4-3-7-34(31)35)69-51(82)41(22-32-24-59-28-64-32)70-48(79)36-15-16-45(76)65-36/h3-4,7-8,11-14,23-24,28-29,36-43,61,73-74H,5-6,9-10,15-22,25-27H2,1-2H3,(H2,56,75)(H,59,64)(H,62,84)(H,63,78)(H,65,76)(H,66,77)(H,67,80)(H,68,83)(H,69,82)(H,70,79)(H,71,81)(H4,57,58,60)/t36-,37-,38-,39-,40-,41-,42-,43-/m0/s1

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