Tissue Repair & Regeneration

Hexapeptide-9

Last updated 12 August 2026

Evidence on file1 animal study · 4 citations not yet graded

Strongest sourceIn Vivo and Ex Vivo Evaluation of a Novel Method for Topical Delivery of Macromolecules Through the Stratum C… (animal study)

Manufacturer’s claim vendor marketing

For a proprietary cosmetic ingredient the manufacturer is the originator — there is no upstream to defer to, and this is often the only description that exists. It is reproduced as an attributed claim, with the label its source gave it. It is not graded and it is not evidence — the graded studies are under Literature.

Vendor claim (SpecialChem/Ashland datasheet): "Acts as an anti-wrinkle and skin repairing agent. It helps in reducing the length and depth of wrinkles. It enhances epidermal regeneration, protein synthesis and boosts dermal-epidermal junction key proteins." No n= or duration on fetched page.

Manufacturer: Ashland
Sold as: Collaxyl IS

Source page — nofollow, because a vendor link is a reference here, not an endorsement.

Dosing on file unverified

0.002% CHP-9 serum, 1-2x/day (56 days)

Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.

Literature on file 5

animal in vivo
In Vivo and Ex Vivo Evaluation of a Novel Method for Topical Delivery of Macromolecules Through the Stratum Corneum for Cosmetic Applications. graded on: an animal model — “In Vivo”

Not graded

4 citations whose study design could not be read from the title. Left ungraded rather than guessed at.

Identity

Space-filling 3D model of Hexapeptide-9, carbon grey, nitrogen blue, oxygen red — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

2D chemical structure of Hexapeptide-9 — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

Molecular weight: 582.6
Molecular formula: C24H38N8O9
CAS number: 885024-94-2
PubChem CID: 16129319
InChI key: OGNHOGPWQTWKGQ-VGWMRTNUSA-N
SMILES: C1C[C@H](N(C1)C(=O)CN)C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)N2CCC[C@H]2C(=O)N[C@@H](CCC(=O)N)C(=O)O
InChI: InChI=1S/C24H38N8O9/c25-11-19(35)31-9-1-3-15(31)22(38)29-13(5-7-17(26)33)21(37)28-12-20(36)32-10-2-4-16(32)23(39)30-14(24(40)41)6-8-18(27)34/h13-16H,1-12,25H2,(H2,26,33)(H2,27,34)(H,28,37)(H,29,38)(H,30,39)(H,40,41)/t13-,14-,15-,16-/m0/s1

Also called

Collaxyl IS
Hexapeptide-9

Notes unverified prose

2025 RCT: cyclized Hexapeptide-9 (CHP-9) outperformed retinol for skin aging at 56 days; 28-day study: improved elasticity & firmness; RCT: cyclized hexapeptide-9 (CHP-9) outperformed retinol

Not on file 1

1 of the 8 fields we track hold nothing on this record, and each says why. A blank field is a bug; a named absence is a finding.

amino-acid sequencenothing we hold supplies it

Each field links to every other record missing the same thing. The full ledger holds 521 gaps across 136 records.