IGF-1 LR3

Mechanism

Modified IGF-1 with extended half-life affecting PI3K-Akt-mTOR and satellite cells.

Reported effects

What sources associate with this compound. Reported categories, not outcomes we have graded — each would need its own citation and rung.

• Muscle repair
• Satellite-cell activation
• Collagen synthesis

Literature on file 7

• animal in vivo
  Long R3 insulin-like growth factor-I (IGF-I) infusion stimulates organ growth but reduces plasma IGF-I, IGF-II and IGF binding protein concentrations in the guinea pig (Journal of Endocrinology 1995, cited 20x) graded on: an animal model — “pig”
• animal in vivo
  IGF-1 LR3 does not promote growth in late-gestation growth-restricted fetal sheep. graded on: an animal model — “sheep”
• animal in vivo
  Revolutionary decellularized Alstroemeria stem-based nerve conduit integrated with GelMA and controlled IGF-1 LR3 release for enhanced rat sciatic nerve regeneration. graded on: an animal model — “rat”

Not graded

4 citations whose study design could not be read from the title. Left ungraded rather than guessed at.

• not graded
  Detection of His-tagged Long-R3-IGF-I in a black market product (Growth Hormone & IGF Research 2010, cited 33x)
• not graded
  The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration.
• not graded
  Therapeutic Peptides in Aesthetic, Metabolic and Endocrine Conditions: Effects, Safety, Clinical Applications, and Future Perspectives.
• not graded
  IGF-1 Increases Collagen Deposition by Dermal Fibroblasts: Applications for Tissue Engineering.

Identity

Classified as

mTOR Signalingmechanism

Direction matters more here than almost anywhere else on the site. The muscle literature is interested in raising mTOR activity and the longevity literature in lowering it, and one word covers both, so the record has to state which.

Growth Hormone / IGF-1 Axispathway

The lab value people actually track, IGF-1 in ng/mL, sits two steps downstream of where most of these compounds act, so a record's mechanism and its measurable marker are rarely the same thing.

Subcutaneousroute

This is the route the reconstitution arithmetic assumes. Mass divided by diluent volume gives concentration, dose divided by concentration gives volume, and volume in mL multiplied by 100 gives units on a U-100 barrel: 5 mg in 2 mL is 2.5 mg/mL, and 0.25 mg comes out at 0.1 mL, which is 10 units.

Also called

• IGF-1 LR3

Listed prices 1

What 1 shop we track listed for IGF-1 LR3, read from their own public catalogues on 2026-08-12. We take no commission on these and they are not ranked by any payment — how vendors are scored.