Growth Hormone & Performance

Ipamorelin

A cleaner GH secretagogue signal with lower spillover profile.

Last updated 12 August 2026

Studied forDeeper sleep · Recovery support · Training capacity

Evidence on file1 human observational study · 2 citations not yet graded

Strongest sourceNCT01280344: Phase II Double-Blind Placebo-Controlled Dose Finding Study to Evaluate Safety/Efficacy of Ipamo… (human observational study)

Mechanism

Selective GHS-R agonist that promotes GH release without expected prolactin/cortisol elevation.

Reported effects

What sources associate with this compound. Reported categories, not outcomes we have graded — each would need its own citation and rung.

Deeper sleep
Recovery support
Training capacity

Dosing on file unverified

100-300 mcg daily, cycled 8–12 weeks

Reported dose	Volume	Draw
Low — 100 mcg	0.1 mL	10 units
High — 300 mcg	0.3 mL	30 units

What that assumes. Assumes 2 mg in 2 mL (1000 mcg/mL) drawn on a U-100 barrel — the preset on this record, not a recommendation and not the only way to mix it. Change the vial mass, the diluent or the barrel and every number in this table changes. Run your own.

Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.

Reconstitution

Vial	Diluent	Concentration	Typical dose	Draw
2 mg	2 mL	1000 mcg/mL	100 mcg	10 units

mass ÷ diluent = concentration; dose ÷ concentration = volume; volume × the syringe factor = units on the barrel (100 for U-100, 40 for U-40). Run your own numbers.

Reported adverse effects

Water retention

Reportedonset: First weeksreported reversible
Headache

Reportedonset: Post-injectionreported reversible
Injection site reaction

Reportedonset: Immediatereported reversible

Literature on file 3

human observational
NCT01280344: Phase II Double-Blind Placebo-Controlled Dose Finding Study to Evaluate Safety/Efficacy of Ipamorelin Compared to Placebo for Recovery of Gastrointestinal Function in Patients Following Small or Large Bowel Resection w/Primary Anastomosis graded on: a registered clinical study — “clinicaltrials.gov”

Not graded

2 citations whose study design could not be read from the title. Left ungraded rather than guessed at.

Identity

Space-filling 3D model of Ipamorelin, carbon grey, nitrogen blue, oxygen red — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

2D chemical structure of Ipamorelin — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

Molecular weight: 711.868
Molecular formula: C38H49N9O5
CAS number: 170851-70-4
PubChem CID: 9831659
InChI key: NEHWBYHLYZGBNO-BVEPWEIPSA-N
Sequence: XHXFK
SMILES: CC(C)(C(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@H](CC2=CC3=CC=CC=C3C=C2)C(=O)N[C@H](CC4=CC=CC=C4)C(=O)N[C@@H](CCCCN)C(=O)N)N
InChI: InChI=1S/C38H49N9O5/c1-38(2,41)37(52)47-32(21-28-22-42-23-43-28)36(51)46-31(20-25-15-16-26-12-6-7-13-27(26)18-25)35(50)45-30(19-24-10-4-3-5-11-24)34(49)44-29(33(40)48)14-8-9-17-39/h3-7,10-13,15-16,18,22-23,29-32H,8-9,14,17,19-21,39,41H2,1-2H3,(H2,40,48)(H,42,43)(H,44,49)(H,45,50)(H,46,51)(H,47,52)/t29-,30+,31+,32-/m0/s1

Classified as

Ghrelin Receptor Agonismmechanism: This is the mechanism behind the compounds usually filed as secretagogues, and it explains why appetite effects appear in the same records as growth hormone effects rather than as an unrelated aside.
Subcutaneousroute: This is the route the reconstitution arithmetic assumes. Mass divided by diluent volume gives concentration, dose divided by concentration gives volume, and volume in mL multiplied by 100 gives units on a U-100 barrel: 5 mg in 2 mL is 2.5 mg/mL, and 0.25 mg comes out at 0.1 mL, which is 10 units.
Intravenousroute: A large share of the pharmacokinetic numbers attached to peptide records, half-life in particular, come from intravenous studies and often from animals. Those numbers describe an intravenous curve and do not transfer unchanged to a depot under the skin.

Also called

Ipamorelin

Notes unverified prose

Phase 2 (NCT01280344); IV 0.03-0.18 mg/kg/day; FDA IND

Not on file 0

All 8 tracked fields hold a value on this record: molecular weight and formula, CAS number, PubChem CID, amino-acid sequence, SMILES, InChI and InChI key.

Counted from the record itself, not from what a source said it was missing. 136 of 185 records still have at least one empty.

Listed prices 7

What 7 shops we track listed for Ipamorelin, read from their own public catalogues on 2026-08-12. We take no commission on these and they are not ranked by any payment — how vendors are scored.

Listed in CAD
Vendor	Size	Price	Per mg
Particle Peptides Canada	5 mg	$27.68 CAD	$5.54/mg
Buy Peptides 4 Research Canada	size not listed	$16.99 CAD	—
Maple Leaf Peptides	size not listed	$64.95 CAD	—

Listed in GBP
Vendor	Size	Price	Per mg
Direct Peptides Canada	size not listed	£12.38 GBP	—
Direct Peptides USA	size not listed	£12.38 GBP	—

Listed in USD
Vendor	Size	Price	Per mg
GenX Peptides	2 mg	$22.00 USD	$11.00/mg

Currency not stated by the vendor — these are not compared with any priced row
Vendor	Size	Price	Per mg
The Peptide CA	10 mg	74.99 (currency not stated)

Prices are the vendor's own listing, reproduced with the date we read it — never converted between currencies, and compared per milligram only where the vendor states the vial size.

At a glance

Strongest rung: human observational
Citations: 3
Regulatory: In or past clinical trials (verified)
Route: Intravenous / Subcutaneous
Declared gaps: 0

Citations by rung

human observational1

Strongest wins, never an average.