Gastrointestinal Health

KPV

An anti-inflammatory peptide fragment for mucosal and swelling research.

Last updated 12 August 2026

Studied forMucosal inflammation support · IBD symptom research · Post-injury swelling

Evidence on file1 animal study · 1 citation not yet graded

Strongest sourcePepT1-Mediated Tripeptide KPV Uptake Reduces Intestinal Inflammation (Gastroenterology 2008, cited 111x) (animal study)

Mechanism

Alpha-MSH fragment associated with NF-kB down-regulation and mast-cell stabilization.

Reported effects

What sources associate with this compound. Reported categories, not outcomes we have graded — each would need its own citation and rung.

Mucosal inflammation support
IBD symptom research
Post-injury swelling

Dosing on file unverified

200-500 mcg daily, cycled 4–8 weeks

Reported dose	Volume	Draw
Low — 200 mcg	0.2 mL	20 units
High — 500 mcg	0.5 mL	50 units

What that assumes. Assumes 2 mg in 2 mL (1000 mcg/mL) drawn on a U-100 barrel — the preset on this record, not a recommendation and not the only way to mix it. Change the vial mass, the diluent or the barrel and every number in this table changes. Run your own.

Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.

Reconstitution

Vial	Diluent	Concentration	Typical dose	Draw
2 mg	2 mL	1000 mcg/mL	200 mcg	20 units

mass ÷ diluent = concentration; dose ÷ concentration = volume; volume × the syringe factor = units on the barrel (100 for U-100, 40 for U-40). Run your own numbers.

Literature on file 2

animal in vivo
PepT1-Mediated Tripeptide KPV Uptake Reduces Intestinal Inflammation (Gastroenterology 2008, cited 111x) graded on: an animal model — read from the indexed abstract — “Mice”

Not graded

1 citation whose study design could not be read from the title. Left ungraded rather than guessed at.

not graded
Structural modification of the tripeptide KPV by reductive 'glycoalkylation' of the lysine residue (PLOS ONE 2018, cited 6x)

Identity

Space-filling 3D model of KPV, carbon grey, nitrogen blue, oxygen red — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

2D chemical structure of KPV — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

Molecular weight: 402.5
Molecular formula: C16H30N4O4
CAS number: 67727-97-3
PubChem CID: 125672
InChI key: YSPZCHGIWAQVKQ-AVGNSLFASA-N
Sequence: KPV
SMILES: CC(C)[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)N
InChI: InChI=1S/C16H30N4O4/c1-10(2)13(16(23)24)19-14(21)12-7-5-9-20(12)15(22)11(18)6-3-4-8-17/h10-13H,3-9,17-18H2,1-2H3,(H,19,21)(H,23,24)/t11-,12-,13-/m0/s1

Classified as

Subcutaneousroute: This is the route the reconstitution arithmetic assumes. Mass divided by diluent volume gives concentration, dose divided by concentration gives volume, and volume in mL multiplied by 100 gives units on a U-100 barrel: 5 mg in 2 mL is 2.5 mg/mL, and 0.25 mg comes out at 0.1 mL, which is 10 units.
Oralroute: Route sets what a milligram means. An oral figure and an injected figure for the same compound are not comparable amounts, and treating one as the other is one of the commonest ways a record gets misread.

Also called

KPV
KPV (GI)

Notes unverified prose

No human RCTs identified; preclinical only; no FDA approval; No completed human RCTs; No human RCTs

Not on file 0

All 8 tracked fields hold a value on this record: molecular weight and formula, CAS number, PubChem CID, amino-acid sequence, SMILES, InChI and InChI key.

Counted from the record itself, not from what a source said it was missing. 136 of 185 records still have at least one empty.