Cognitive & Neuroprotection

Leu-Enkephalin

Last updated 12 August 2026

Evidence on file2 animal studies · 1 in-vitro study · 3 citations not yet graded

Strongest sourceMet-enkephalin and other opioid peptides in the stress response of chickens: lessons from laboratory animals… (animal study)

Dosing on file unverified

Envelta (nanotechnology delivery): human study completed; Dalargin (leu-enkephalin) in development; No established dose

Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.

Literature on file 6

in vitro
MALDI-induced fragmentation of leucine enkephalin, nitro-Tyr-leucine enkaphalin, and d5-Phe-nitro-Tyr-leucine enkephalin (2009, cited 21x) graded on: an in-vitro system — read from the indexed abstract — “in vitro”
animal in vivo
Met-enkephalin and other opioid peptides in the stress response of chickens: lessons from laboratory animals and livestock. graded on: an animal model — “chickens”
animal in vivo
Cytoprotective Effect of NOP Receptor Blockade in Primary Culture of Pulmonary Fibroblasts. graded on: an animal model — read from the indexed abstract — “Rats”

Not graded

3 citations whose study design could not be read from the title. Left ungraded rather than guessed at.

Identity

Space-filling 3D model of Leu-Enkephalin, carbon grey, nitrogen blue, oxygen red — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

2D chemical structure of Leu-Enkephalin — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

Molecular weight: 555.6
Molecular formula: C28H37N5O7
CAS number: 58822-25-6
PubChem CID: 461776
UniProt: P01210 (precursor)
InChI key: URLZCHNOLZSCCA-VABKMULXSA-N
SMILES: CC(C)C[C@@H](C(=O)O)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)[C@H](CC2=CC=C(C=C2)O)N
InChI: InChI=1S/C28H37N5O7/c1-17(2)12-23(28(39)40)33-27(38)22(14-18-6-4-3-5-7-18)32-25(36)16-30-24(35)15-31-26(37)21(29)13-19-8-10-20(34)11-9-19/h3-11,17,21-23,34H,12-16,29H2,1-2H3,(H,30,35)(H,31,37)(H,32,36)(H,33,38)(H,39,40)/t21-,22-,23-/m0/s1

Notes unverified prose

Nanomerics completed human study with MET technology; Envelta for pain; no moderate-severe adverse events; Phase I gene therapy trial; Envelta intranasal (nanotechnology); dalargin

Not on file 1

1 of the 8 fields we track hold nothing on this record, and each says why. A blank field is a bug; a named absence is a finding.

amino-acid sequencenothing we hold supplies it

Each field links to every other record missing the same thing. The full ledger holds 521 gaps across 136 records.