Cognitive & Neuroprotection

Met-Enkephalin

Last updated 12 August 2026

Evidence on file1 randomised human trial · 1 animal study · 1 citation not yet graded

Strongest sourceNCT04374032: An Open-label, Prospective, Randomized, Comparative Clinical Trial to Evaluate the Efficacy and… (randomised human trial)

Dosing on file unverified

FK 33-824 analogue: 2 mg IM daily for 7 days (schizophrenia study); Phase 2 for pancreatic cancer, HIV; No standard dose

Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.

Literature on file 3

human RCT
NCT04374032: An Open-label, Prospective, Randomized, Comparative Clinical Trial to Evaluate the Efficacy and Safety of ENKORTEN® as an Immunomodulatory Therapy graded on: a randomised trial — “Randomized, Comparative Clinical Trial”
animal in vivo
Immunohistochemical localization of enkephalin in rat brain and spinal cord (Journal of Comparative Neurology 1978, cited 684x) graded on: an animal model — “rat”

Not graded

1 citation whose study design could not be read from the title. Left ungraded rather than guessed at.

not graded
Primary structure of the human Met- and Leu-enkephalin precursor and its mRNA (Nature 1982, cited 554x)

Identity

Space-filling 3D model of Met-Enkephalin, carbon grey, nitrogen blue, oxygen red — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

2D chemical structure of Met-Enkephalin — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

Molecular weight: 573.7
Molecular formula: C27H35N5O7S
CAS number: 58569-55-4
PubChem CID: 443363
UniProt: P01210 (precursor)
InChI key: YFGBQHOOROIVKG-FKBYEOEOSA-N
SMILES: CSCC[C@@H](C(=O)O)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)[C@H](CC2=CC=C(C=C2)O)N
InChI: InChI=1S/C27H35N5O7S/c1-40-12-11-21(27(38)39)32-26(37)22(14-17-5-3-2-4-6-17)31-24(35)16-29-23(34)15-30-25(36)20(28)13-18-7-9-19(33)10-8-18/h2-10,20-22,33H,11-16,28H2,1H3,(H,29,34)(H,30,36)(H,31,35)(H,32,37)(H,38,39)/t20-,21-,22-/m0/s1

Notes unverified prose

Phase 2 for pancreatic cancer, HIV; Phase 2/3 for COVID-19 (NCT04374032); FK 33-824 2 mg IM daily in schizophrenia crossover study; Phase 2 (pancreatic cancer, HIV); NCT04374032 (COVID-19)

Not on file 1

1 of the 8 fields we track hold nothing on this record, and each says why. A blank field is a bug; a named absence is a finding.

amino-acid sequencenothing we hold supplies it

Each field links to every other record missing the same thing. The full ledger holds 521 gaps across 136 records.