MK-677

Mechanism

Small-molecule GHS-R1a agonist that raises GH and IGF-1 orally.

Reported effects

What sources associate with this compound. Reported categories, not outcomes we have graded — each would need its own citation and rung.

• Lean-mass gain
• GH/IGF-1 elevation
• Oral convenience

Literature on file 7

• human observational
  Systematic review of undeclared prohibited substances and pharmacological adulterants in dietary supplements: prevalence, detection, and risks in sport. graded on: a synthesis of human studies — “Systematic review”
• human observational
  NCT00474279: Effects of an Oral GH Secretagogue (MK-677) on Body Composition and Functional Ability of Older Adults graded on: a registered clinical study — “clinicaltrials.gov”

Not graded

5 citations whose study design could not be read from the title. Left ungraded rather than guessed at.

• not graded
  Ibutamoren Mesylate (2006)
• not graded
  Therapeutic Peptides in Aesthetic, Metabolic and Endocrine Conditions: Effects, Safety, Clinical Applications, and Future Perspectives.
• not graded
  Knowing the minimal detectable dose can facilitate the interpretation of a hair test result: II. Case example with ibutamoren (MK-677), a growth hormone secretagogue.
• not graded
  Acute stress suppresses hunger-driven food seeking through PVN activation: Reversal by anxiolytic drug and ghrelin receptor agonist, with anxiolytic-like effects of refeeding.
• not graded
  Growth Hormone Secretagogues as Potential Therapeutic Agents to Restore Growth Hormone Secretion in Older Subjects to Those Observed in Young Adults.

Identity

PubChem CID 6450830 computed 3D conformer

Skeletal formulathe canonical depiction

Drawn by PubChem from CID 6450830, the identifier on this record.

Molecular weight

624.8

Molecular formula

C28H40N4O8S2

CAS number

159752-10-0

PubChem CID

6450830

InChI key

DUGMCDWNXXFHDE-VZYDHVRKSA-N

SMILES

CC(C)(C(=O)N[C@H](COCC1=CC=CC=C1)C(=O)N2CCC3(CC2)CN(C4=CC=CC=C34)S(=O)(=O)C)N.CS(=O)(=O)O

InChI

InChI=1S/C27H36N4O5S.CH4O3S/c1-26(2,28)25(33)29-22(18-36-17-20-9-5-4-6-10-20)24(32)30-15-13-27(14-16-30)19-31(37(3,34)35)23-12-8-7-11-21(23)27;1-5(2,3)4/h4-12,22H,13-19,28H2,1-3H3,(H,29,33);1H3,(H,2,3,4)/t22-;/m1./s1

Classified as

Ghrelin Receptor Agonismmechanism

This is the mechanism behind the compounds usually filed as secretagogues, and it explains why appetite effects appear in the same records as growth hormone effects rather than as an unrelated aside.

Growth Hormone / IGF-1 Axispathway

The lab value people actually track, IGF-1 in ng/mL, sits two steps downstream of where most of these compounds act, so a record's mechanism and its measurable marker are rarely the same thing.

Oralroute

Route sets what a milligram means. An oral figure and an injected figure for the same compound are not comparable amounts, and treating one as the other is one of the commonest ways a record gets misread.

Also called

• MK-677
• MK-677 (Ibutamoren)

Listed prices 14

What 10 shops we track listed for MK-677, read from their own public catalogues on 2026-08-12. We take no commission on these and they are not ranked by any payment — how vendors are scored.

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