Longevity & Cellular Health; Cognitive & Neuroprotection

N-Acetylcysteine (NAC)

Last updated 12 August 2026

Evidence on file7 human observational studies · 3 citations not yet graded

Strongest sourceThe efficacy of N-acetylcysteine in the management of chronic obstructive pulmonary disease: a systematic rev… (human observational study)

Dosing on file unverified

Oral: 600-2,400 mg/day; IV: load 150 mg/kg then 15 mg/kg/h; Oral: 600-2,400 mg/day (600 mg 1-4x daily); Acetaminophen: oral load 140 mg/kg then 70 mg/kg q4h

Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.

Literature on file 10

human observational
The efficacy of N-acetylcysteine in the management of chronic obstructive pulmonary disease: a systematic review and meta-analysis. graded on: a synthesis of human studies — “systematic review”
human observational
Therapeutic effect of N-acetylcysteine in severe or critical coronavirus disease 2019 pneumonia: A retrospective cohort study. graded on: an observational human design — “retrospective”
human observational
NCT03252925: A Safety and Efficacy Study of N-acetylcysteine in Patients With Transplant-Associated Thrombotic Microangiopathy graded on: a registered clinical study — “clinicaltrials.gov”
human observational
NCT01501110: Evaluation of the Effects of N-acetylcysteine on Thyroid Hormone Levels in the Low T3 Syndrome graded on: a registered clinical study — “clinicaltrials.gov”
human observational
NCT00542750: An Open-Label Trial of N-Acetylcysteine in Cannabis Dependent Adolescents graded on: a registered clinical study — “clinicaltrials.gov”
human observational
NCT00552786: Antioxidation Medication for Noise-induced Hearing Loss graded on: a registered clinical study — “clinicaltrials.gov”
human observational
NCT00724594: Safety of N-acetylcysteine in Maternal Chorioamnionitis graded on: a registered clinical study — “clinicaltrials.gov”

Not graded

3 citations whose study design could not be read from the title. Left ungraded rather than guessed at.

Identity

Space-filling 3D model of N-Acetylcysteine (NAC), carbon grey, nitrogen blue, oxygen red — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

2D chemical structure of N-Acetylcysteine (NAC) — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

Molecular weight: 163.20
Molecular formula: C5H9NO3S
CAS number: 616-91-1
PubChem CID: 12035
ChEMBL: CHEMBL600
InChI key: PWKSKIMOESPYIA-BYPYZUCNSA-N
SMILES: CC(=O)N[C@@H](CS)C(=O)O
InChI: InChI=1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1

Also called

N-Acetylcysteine (NAC) (Longevity)

Notes unverified prose

Numerous RCTs; standard clinical use; Standard oral anti-inflammatory: 600 mg 1-2x/day; IV NAC 50 mg/kg weekly + oral 500 mg BID

Not on file 1

1 of the 8 fields we track hold nothing on this record, and each says why. A blank field is a bug; a named absence is a finding.

amino-acid sequencenot applicable to this compound

Each field links to every other record missing the same thing. The full ledger holds 521 gaps across 136 records.