Miscellaneous & Research; Cognitive & Neuroprotection

Neurotensin

Last updated 12 August 2026

Evidence on file1 human observational study · 1 animal study · 1 citation not yet graded

Strongest sourceNCT04179331: Neurotensin Infusions in Healthy Individuals - Effects on Appetite, Food Intake, Hormone Secreti… (human observational study)

Dosing on file unverified

2.5, 5.0, 7.5 pmol/kg/min sequential IV infusion (each 1h); 2.3 pmol/kg/min for 30 min; 2.5-7.5 pmol/kg/min IV infusion (1h each dose, sequential)

Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.

Literature on file 3

human observational
NCT04179331: Neurotensin Infusions in Healthy Individuals - Effects on Appetite, Food Intake, Hormone Secretions and Cardiovascular Responses graded on: a registered clinical study — “clinicaltrials.gov”
animal in vivo
The Isolation of a New Hypotensive Peptide, Neurotensin, from Bovine Hypothalami (Journal of Biological Chemistry 1973, cited 1324x) graded on: an animal model — “Bovine”

Not graded

1 citation whose study design could not be read from the title. Left ungraded rather than guessed at.

not graded
Neurotensin and neurotensin receptors (Trends in Pharmacological Sciences 1999, cited 493x)

Identity

Space-filling 3D model of Neurotensin, carbon grey, nitrogen blue, oxygen red — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

2D chemical structure of Neurotensin — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

Molecular weight: 1672.9
Molecular formula: C78H121N21O20
CAS number: 39379-15-2
PubChem CID: 25077406
UniProt: P30990 (precursor)
InChI key: PCJGZPGTCUMMOT-ISULXFBGSA-N
SMILES: CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)O)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]5CCC(=O)N5
InChI: InChI=1S/C78H121N21O20/c1-7-43(6)63(73(115)96-57(76(118)119)37-42(4)5)97-70(112)55(39-45-21-25-47(101)26-22-45)95-72(114)59-18-13-35-99(59)75(117)52(16-11-33-86-78(83)84)90-64(106)48(15-10-32-85-77(81)82)89-71(113)58-17-12-34-98(58)74(116)51(14-8-9-31-79)91-69(111)56(40-60(80)102)94-66(108)50(28-30-62(104)105)88-68(110)54(38-44-19-23-46(100)24-20-44)93-67(109)53(36-41(2)3)92-65(107)49-27-29-61(103)87-49/h19-26,41-43,48-59,63,100-101H,7-18,27-40,79H2,1-6H3,(H2,80,102)(H,87,103)(H,88,110)(H,89,113)(H,90,106)(H,91,111)(H,92,107)(H,93,109)(H,94,108)(H,95,114)(H,96,115)(H,97,112)(H,104,105)(H,118,119)(H4,81,82,85)(H4,83,84,86)/t43-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,63-/m0/s1

Caveat on these identifiers

Source files disagreed on evidence tier for this peptide.

Notes unverified prose

NCT04179331; 2.3 pmol/kg/min in healthy subjects; NCT04179331: 2.5, 5.0, 7.5 pmol/kg/min sequential IV infusions; NCT04179331 (2.5, 5.0, 7.5 pmol/kg/min IV); NCT04179331 (human IV infusions)

Not on file 1

1 of the 8 fields we track hold nothing on this record, and each says why. A blank field is a bug; a named absence is a finding.

amino-acid sequencenothing we hold supplies it

Each field links to every other record missing the same thing. The full ledger holds 521 gaps across 136 records.