Tissue Repair & Regeneration

Nonapeptide-1

Last updated 12 August 2026

Evidence on file1 randomised human trial · 2 animal studies · 2 in-vitro studies

Strongest sourceEffect of a New Skin-Lightening Cosmetic Containing Cordyceps Extract in the Treatment of Melasma: A Clinical… (randomised human trial)

Manufacturer’s claim vendor marketing

For a proprietary cosmetic ingredient the manufacturer is the originator — there is no upstream to defer to, and this is often the only description that exists. It is reproduced as an attributed claim, with the label its source gave it. It is not graded and it is not evidence — the graded studies are under Literature.

SpecialChem INCI page (fetched): general benefits of "inhibiting melanin production" and "promoting collagen synthesis"; no quantified data or study parameters given.

Manufacturer: Lucas Meyer Cosmetics (from lucasmeyercosmetics.com search-result listing title; direct page fetch returned 404)
Sold as: Melanostatine 5 (search-listing evidence); fetch-verified alternatives: WKPep Whitenin (Shenzhen Winkey)
Manufacturer’s recommended use: 50-500 ppm (0.005-0.05%) in aqueous systems (per tcspeptides.com fetched page)

Source page — nofollow, because a vendor link is a reference here, not an endorsement.

Dosing on file unverified

0.0025-4% in creams, 1-2x/day

Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.

Literature on file 5

human RCT
Effect of a New Skin-Lightening Cosmetic Containing Cordyceps Extract in the Treatment of Melasma: A Clinical Trial. graded on: names a randomised controlled trial — the indexed publication type — “Randomized Controlled”
in vitro
Discovery of a Novel Cyclopeptide as Tyrosinase Inhibitor for Skin Lightening. graded on: an in-vitro system — read from the indexed abstract — “assay”
animal in vivo
Natural dual inhibitor isorhamnetin-3-O-neohespeidoside targets tyrosinase and MC1R for skin pigmentation management. graded on: an animal model — read from the indexed abstract — “Mice”
animal in vivo
Enhanced skin benefits of EGCG loaded in nonapeptide-1-conjugated mesoporous silica nanoparticles to reverse skin photoaging. graded on: an animal model — read from the indexed abstract — “Mice”
in vitro
Effects of tea polyphenols on UVA-induced melanogenesis via inhibition of α-MSH-MC1R signalling pathway. graded on: an in-vitro system — read from the indexed abstract — “cell line”

Identity

Space-filling 3D model of Nonapeptide-1, carbon grey, nitrogen blue, oxygen red — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

2D chemical structure of Nonapeptide-1 — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

Molecular weight: 1206.5
Molecular formula: C61H87N15O9S
CAS number: 158563-45-2
PubChem CID: 10418849
InChI key: KNFLNGRLKALWRF-LDXSYGEZSA-N
SMILES: CC(C)[C@@H](C(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](CC5=CC=CC=C5)NC(=O)[C@@H]6CCCN6C(=O)[C@H](CCSC)N
InChI: InChI=1S/C61H87N15O9S/c1-37(2)51(52(64)77)74-58(83)50-26-16-31-76(50)60(85)45(23-12-13-28-62)70-55(80)46(33-38-17-6-4-7-18-38)71-56(81)48(35-40-36-68-43-22-11-10-21-41(40)43)72-53(78)44(24-14-29-67-61(65)66)69-54(79)47(34-39-19-8-5-9-20-39)73-57(82)49-25-15-30-75(49)59(84)42(63)27-32-86-3/h4-11,17-22,36-37,42,44-51,68H,12-16,23-35,62-63H2,1-3H3,(H2,64,77)(H,69,79)(H,70,80)(H,71,81)(H,72,78)(H,73,82)(H,74,83)(H4,65,66,67)/t42-,44-,45-,46-,47+,48+,49-,50-,51-/m0/s1

Also called

Melanostatine 5
Nonapeptide-1

Notes unverified prose

RCT: proprietary combination with sunscreen for melasma maintenance; 28-day (n=41, 0.0025%): luminosity +3.5%, wrinkles -15.4%; 6-week (4%): age spots -25%; Double-blind clinical study (4%, 8 weeks); J Invest Dermatol 2008

Not on file 1

1 of the 8 fields we track hold nothing on this record, and each says why. A blank field is a bug; a named absence is a finding.

amino-acid sequencenothing we hold supplies it

Each field links to every other record missing the same thing. The full ledger holds 521 gaps across 136 records.