Cognitive & Neuroprotection

Noopept

Last updated 12 August 2026

Evidence on file3 animal studies · 2 in-vitro studies · 6 citations not yet graded

Strongest sourceThe nootropic and neuroprotective proline-containing dipeptide noopept restores spatial memory and increases… (animal study)

Dosing on file unverified

Oral/Sublingual: 10-30 mg/day split AM/PM; Intranasal: 2-5 mg/day (approx 10% of oral dose)

Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.

Literature on file 11

in vitro
GVS-111 prevents oxidative damage and apoptosis in normal and Down's syndrome human cortical neurons. graded on: an in-vitro system — read from the indexed abstract — “in vitro”
animal in vivo
The nootropic and neuroprotective proline-containing dipeptide noopept restores spatial memory and increases immunoreactivity to amyloid in an Alzheimer's disease model. graded on: an animal model — read from the indexed abstract — “Mice”
in vitro
Cognitive Enhancer Noopept Activates Transcription Factor HIF-1. graded on: an in-vitro system — read from the indexed abstract — “in vitro”
animal in vivo
Effect of nootropic dipeptide noopept on CA1 pyramidal neurons involves α7AChRs on interneurons in hippocampal slices from rat. graded on: an animal model — “rat”
animal in vivo
Noopept Attenuates Diabetes-Mediated Neuropathic Pain and Oxidative Hippocampal Neurotoxicity via Inhibition of TRPV1 Channel in Rats. graded on: an animal model — “Rats”

Not graded

6 citations whose study design could not be read from the title. Left ungraded rather than guessed at.

Identity

Space-filling 3D model of Noopept, carbon grey, nitrogen blue, oxygen red — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

2D chemical structure of Noopept — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

Molecular weight: 318.4
Molecular formula: C17H22N2O4
CAS number: 157115-85-0
PubChem CID: 180496
InChI key: PJNSMUBMSNAEEN-AWEZNQCLSA-N
SMILES: CCOC(=O)CNC(=O)[C@@H]1CCCN1C(=O)CC2=CC=CC=C2
InChI: InChI=1S/C17H22N2O4/c1-2-23-16(21)12-18-17(22)14-9-6-10-19(14)15(20)11-13-7-4-3-5-8-13/h3-5,7-8,14H,2,6,9-12H2,1H3,(H,18,22)/t14-/m0/s1

Notes unverified prose

Approved in Russia; typical dose 10-30 mg; oral bioavailability data: peak 13-33 µg/L at 1h post 20 mg; intranasal ~3mg per spray; 10-30 mg/day oral

Not on file 1

1 of the 8 fields we track hold nothing on this record, and each says why. A blank field is a bug; a named absence is a finding.

amino-acid sequencenothing we hold supplies it

Each field links to every other record missing the same thing. The full ledger holds 521 gaps across 136 records.

Listed prices 1

What 1 shop we track listed for Noopept, read from their own public catalogues on 2026-08-12. We take no commission on these and they are not ranked by any payment — how vendors are scored.

Listed in USD
Vendor	Size	Price	Per mg
Cosmic Nootropic ships worldwide	size not listed	$20.00 USD ~~$32.00 USD~~	—

Prices are the vendor's own listing, reproduced with the date we read it — never converted between currencies, and compared per milligram only where the vendor states the vial size.