Cognitive & Neuroprotection
P21
A neuroplasticity-oriented peptide for learning and recovery research.
Last updated
Mechanism
Associated with BDNF up-regulation and synaptic plasticity enhancement.
Reported effects
What sources associate with this compound. Reported categories, not outcomes we have graded — each would need its own citation and rung.
- Motor learning
- Neuroplasticity
- Post-TBI recovery
Dosing on file unverified
100-500 mcg daily, cycled 4–8 weeks
| Reported dose | Volume | Draw |
|---|---|---|
| Low — 100 mcg | 0.1 mL | 10 units |
| High — 500 mcg | 0.5 mL | 50 units |
What that assumes. Assumes 2 mg in 2 mL (1000 mcg/mL) drawn on a U-100 barrel — the preset on this record, not a recommendation and not the only way to mix it. Change the vial mass, the diluent or the barrel and every number in this table changes. Run your own.
Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.
Reconstitution
| Vial | Diluent | Concentration | Typical dose | Draw |
|---|---|---|---|---|
| 2 mg | 2 mL | 1000 mcg/mL | 100 mcg | 10 units |
mass ÷ diluent = concentration; dose ÷ concentration = volume; volume × the syringe factor = units on the barrel (100 for U-100, 40 for U-40). Run your own numbers.
Literature on file 6
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animal in vivo
Effects of a ciliary neurotrophic factor (CNTF) small-molecule peptide mimetic in an in vitro and in vivo model of CDKL5 deficiency disorder. graded on: an animal model — “in vivo”
- animal in vivo
-
animal in vivo
Neurotrophic Treatment Initiated During Early Postnatal Development Prevents the Alzheimer-Like Behavior and Synaptic Dysfunction. graded on: an animal model — read from the indexed abstract — “Mice”
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animal in vivo
Prenatal to early postnatal neurotrophic treatment prevents Alzheimer-like behavior and pathology in mice. graded on: an animal model — “mice”
-
animal in vivo
Prevention of dendritic and synaptic deficits and cognitive impairment with a neurotrophic compound. graded on: an animal model — read from the indexed abstract — “Mice”
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animal in vivo
Early neurotrophic pharmacotherapy rescues developmental delay and Alzheimer's-like memory deficits in the Ts65Dn mouse model of Down syndrome. graded on: an animal model — “mouse”
Identity
Classified as
- BDNF/TrkB Signalingmechanism
- Nearly every nootropic record on the site points here, so it is where a cognitive claim can be checked against something measurable instead of taken as a description of how someone felt.
- Neuroplasticitypathway
- Nearly every nootropic claim reduces to a claim about this pathway, and the supporting measurement is usually a protein level in rodent brain tissue, an animal_in_vivo finding that does not carry across to human cognition.
Also called
- P21
Not on file 8
8 of the 8 fields we track hold nothing on this record, and each says why. A blank field is a bug; a named absence is a finding.
- molecular weightno source on file holds this
- molecular formulano source on file holds this
- CAS registry numberthe reference database returned nothing for it
- PubChem identifierno source on file holds this
- amino-acid sequenceno source on file holds this
- SMILES stringthe reference database returned nothing for it
- InChIthe reference database returned nothing for it
- InChI keythe reference database returned nothing for it
Each field links to every other record missing the same thing. The full ledger holds 521 gaps across 136 records.