Tissue Repair & Regeneration

Palmitoyl Hexapeptide-12

Last updated 12 August 2026

Evidence on file1 randomised human trial · 5 citations not yet graded

Strongest sourceEfficacy of 1064-Nm Picosecond Nd: YAG Laser in Treating Facial Photoaging and Improving Skin Barrier Enhance… (randomised human trial)

Manufacturer’s claim vendor marketing

For a proprietary cosmetic ingredient the manufacturer is the originator — there is no upstream to defer to, and this is often the only description that exists. It is reproduced as an attributed claim, with the label its source gave it. It is not graded and it is not evidence — the graded studies are under Literature.

Vendor claim quoted from incidecoder: "twice a day application of 4% Biopeptide El improved skin firmness by 33% and skin tone by 20%" - double-blind study, n=10 women, one month.

Manufacturer: Croda (Sederma brand)
Sold as: Biopeptide EL (also appears in Dermaxyl CL and Bio-Bustyl PH blends)
Manufacturer’s recommended use: 4% (concentration used in the clinical study cited by incidecoder)

Source page — nofollow, because a vendor link is a reference here, not an endorsement.

Dosing on file unverified

0.0004% (w/w) cream; 4% Biopeptide EL, 2x/day

Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.

Literature on file 6

human RCT
Efficacy of 1064-Nm Picosecond Nd: YAG Laser in Treating Facial Photoaging and Improving Skin Barrier Enhanced by a Multi-Beneficial Composition Formulation: A Blinded Randomized Clinical Trial Study. graded on: names a randomised controlled trial — “Randomized Clinical Trial”

Not graded

5 citations whose study design could not be read from the title. Left ungraded rather than guessed at.

Identity

Space-filling 3D model of Palmitoyl Hexapeptide-12, carbon grey, nitrogen blue, oxygen red — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

2D chemical structure of Palmitoyl Hexapeptide-12 — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

Molecular weight: 737.0
Molecular formula: C38H68N6O8
CAS number: 171263-26-6
PubChem CID: 10212452
InChI key: JFSQSDAOQLNSQI-DTBJPNGVSA-N
SMILES: CCCCCCCCCCCCCCCC(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O
InChI: InChI=1S/C38H68N6O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-22-30(45)42-33(26(2)3)36(50)39-24-31(46)43-34(27(4)5)37(51)41-28(6)38(52)44-23-20-21-29(44)35(49)40-25-32(47)48/h26-29,33-34H,7-25H2,1-6H3,(H,39,50)(H,40,49)(H,41,51)(H,42,45)(H,43,46)(H,47,48)/t28-,29-,33-,34-/m0/s1

Also called

Biopeptide EL
Glycine, N-
Palmitoyl Hexapeptide-12

Notes unverified prose

1-month DB study (n=10, 4%): skin firmness +33%, skin tone +20%; 14-day study: 81.8-100% reported relief; Sederma data; Double-blind study (n=10, 1 month): 20% firmness, 33% tone

Not on file 1

1 of the 8 fields we track hold nothing on this record, and each says why. A blank field is a bug; a named absence is a finding.

amino-acid sequencenothing we hold supplies it

Each field links to every other record missing the same thing. The full ledger holds 521 gaps across 136 records.