Tissue Repair & Regeneration

Palmitoyl Tetrapeptide-7

Last updated 12 August 2026

Evidence on file1 human observational study

Strongest sourceNCT05932732: A Phase IV Open-label Trial Assessing the Impact on Skin Quality, Hydration, and Barrier of Thre… (human observational study)

Manufacturer’s claim vendor marketing

For a proprietary cosmetic ingredient the manufacturer is the originator — there is no upstream to defer to, and this is often the only description that exists. It is reproduced as an attributed claim, with the label its source gave it. It is not graded and it is not evidence — the graded studies are under Literature.

Vendor claims quoted from fetched page: "collagen-boosting properties that target wrinkles and fine lines"; "restore the skin's firmness and elasticity by supporting the skin's structural components"; "reduce fine lines, wrinkles, and sagging skin by promoting collagen production". No n= or study duration given on fetched page.

Manufacturer: Croda (Sederma brand)
Sold as: Matrixyl 3000 (blend with Palmitoyl Tripeptide-1); also ActiTide 3000 (Uniproma), Haloxyl (distributed by Brenntag)
Manufacturer’s recommended use: Vendor claim: "generally used in concentrations of 2% to 5% in formulations"

Source page — nofollow, because a vendor link is a reference here, not an endorsement.

Dosing on file unverified

0.1-0.5% in creams, 1-2x/day

Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.

Literature on file 1

human observational
NCT05932732: A Phase IV Open-label Trial Assessing the Impact on Skin Quality, Hydration, and Barrier of Three (3) Hydrafacial Treatments in Adults of Fitzpatrick Skin Types I-VI graded on: a registered clinical study — “clinicaltrials.gov”

Identity

Space-filling 3D model of Palmitoyl Tetrapeptide-7, carbon grey, nitrogen blue, oxygen red — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

2D chemical structure of Palmitoyl Tetrapeptide-7 — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

Molecular weight: 694.9
Molecular formula: C34H62N8O7
CAS number: 221227-05-0
PubChem CID: 10078408
InChI key: IHRKJQSLKLYWBQ-QKDODKLFSA-N
SMILES: CCCCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O
InChI: InChI=1S/C34H62N8O7/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-19-29(44)39-24-30(45)40-25(20-21-28(35)43)32(47)42-23-16-18-27(42)31(46)41-26(33(48)49)17-15-22-38-34(36)37/h25-27H,2-24H2,1H3,(H2,35,43)(H,39,44)(H,40,45)(H,41,46)(H,48,49)(H4,36,37,38)/t25-,26-,27-/m0/s1

Also called

ActiTide 3000
Matrixyl 3000
Palmitoyl Tetrapeptide-7

Notes unverified prose

12-week clinical trial: skin hydration +28.12%, elasticity +18.81%, collagen +54.99%; Matrixyl 3000 blend; Phase 4; NCT05932732; Clinical trials in JCAD

Not on file 1

1 of the 8 fields we track hold nothing on this record, and each says why. A blank field is a bug; a named absence is a finding.

amino-acid sequencenothing we hold supplies it

Each field links to every other record missing the same thing. The full ledger holds 521 gaps across 136 records.