Tissue Repair & Regeneration

Palmitoyl Tripeptide-1

Last updated 12 August 2026

Evidence on file1 randomised human trial · 1 human observational study · 1 animal study · 3 citations not yet graded

Strongest sourceComprehensive evaluation of the efficacy and safety of a new multi-component anti-aging topical eye cream. (randomised human trial)

Manufacturer’s claim vendor marketing

For a proprietary cosmetic ingredient the manufacturer is the originator — there is no upstream to defer to, and this is often the only description that exists. It is reproduced as an attributed claim, with the label its source gave it. It is not graded and it is not evidence — the graded studies are under Literature.

Vendor claims quoted from fetched page: stimulates "collagen production, promote[s] skin healing, and improve[s] the overall appearance of the skin"; "reduce the appearance of fine lines, wrinkles, and sagging skin". No n= or study duration given on fetched page.

Manufacturer: Croda (Sederma brand)
Sold as: Matrixyl 3000 (blend with Palmitoyl Tetrapeptide-7); also ActiTide 3000 (Uniproma), MAXI-LIP (distributed by Brenntag)
Manufacturer’s recommended use: Vendor claim: "typically 2% to 5%"

Source page — nofollow, because a vendor link is a reference here, not an endorsement.

Dosing on file unverified

4 ppm to 0.1% in creams, 1-2x/day

Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.

Literature on file 6

human observational
An Open-Label Study to Assess the Efficacy and Tolerability of a Multifunctional, 10-Peptide Face and Neck Serum to Address Skin Quality. graded on: indexed as a clinical trial, design not stated — “Clinical Trial”
human RCT
Comprehensive evaluation of the efficacy and safety of a new multi-component anti-aging topical eye cream. graded on: names a randomised controlled trial — the indexed publication type — “Randomized Controlled”
animal in vivo
Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism. graded on: an animal model — read from the indexed abstract — “Mice”

Not graded

3 citations whose study design could not be read from the title. Left ungraded rather than guessed at.

Identity

Space-filling 3D model of Palmitoyl Tripeptide-1, carbon grey, nitrogen blue, oxygen red — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

2D chemical structure of Palmitoyl Tripeptide-1 — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

Molecular weight: 578.8
Molecular formula: C30H54N6O5
CAS number: 147732-56-7
PubChem CID: 10231864
InChI key: BYUQATUKPXLFLZ-UIOOFZCWSA-N
SMILES: CCCCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CCCCN)C(=O)O
InChI: InChI=1S/C30H54N6O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-18-27(37)33-22-28(38)35-26(20-24-21-32-23-34-24)29(39)36-25(30(40)41)17-15-16-19-31/h21,23,25-26H,2-20,22,31H2,1H3,(H,32,34)(H,33,37)(H,35,38)(H,36,39)(H,40,41)/t25-,26-/m0/s1

Also called

ActiTide 3000
Matrixyl 3000
Palmitoyl Tripeptide-1

Notes unverified prose

Clinical trial (n=30): nasolabial fold depth -36.35% at 8-12 weeks; Matrixyl 3000 blend (with tetrapeptide-7) has largest published human cosmetic dataset; Blind randomized clinical study (28 volunteers); Matrixyl 3000 blend

Not on file 1

1 of the 8 fields we track hold nothing on this record, and each says why. A blank field is a bug; a named absence is a finding.

amino-acid sequencenothing we hold supplies it

Each field links to every other record missing the same thing. The full ledger holds 521 gaps across 136 records.