Longevity & Cellular Health

Palmitoyl Tripeptide-38

Last updated 12 August 2026

Evidence on file1 human observational study · 5 citations not yet graded

Strongest sourceAn Open Label Clinical Trial of a Multi-Ingredient Anti-Aging Moisturizer Designed to Improve the Appearance… (human observational study)

Manufacturer’s claim vendor marketing

For a proprietary cosmetic ingredient the manufacturer is the originator — there is no upstream to defer to, and this is often the only description that exists. It is reproduced as an attributed claim, with the label its source gave it. It is not graded and it is not evidence — the graded studies are under Literature.

Vendor claim (INCIDecoder): can "boost the production of 6 major components of the skin matrix" (collagen I, III, IV, fibronectin, hyaluronic acid, laminin 5); "more even skin and fewer wrinkles particularly on the forehead and crow's feet"; "women reported a decrease in wrinkles by 31% up to 100%" after 2 months at 2%. n= not stated on fetched page.

Manufacturer: Sederma (Matrixyl brand owner per fetched INCIDecoder Palmitoyl Pentapeptide-4 page; supplier not restated on the Tripeptide-38 page itself)
Sold as: MATRIXYL synthe'6
Manufacturer’s recommended use: "2% of the active for two months daily" (INCIDecoder)

Source page — nofollow, because a vendor link is a reference here, not an endorsement.

Dosing on file unverified

No established human dose; cosmetic serum concentrations vary

Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.

Literature on file 6

human observational
An Open Label Clinical Trial of a Multi-Ingredient Anti-Aging Moisturizer Designed to Improve the Appearance of Facial Skin. graded on: indexed as a clinical trial, design not stated — “Clinical Trial”

Not graded

5 citations whose study design could not be read from the title. Left ungraded rather than guessed at.

Identity

Space-filling 3D model of Palmitoyl Tripeptide-38, carbon grey, nitrogen blue, oxygen red — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

2D chemical structure of Palmitoyl Tripeptide-38 — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

Molecular weight: 676.0
Molecular formula: C33H65N5O7S
CAS number: 1101448-24-1
PubChem CID: 71587932
InChI key: RGXYBFJDNNODFP-AWCRTANDSA-N
SMILES: CCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCS(=O)(=O)C)C(=O)N[C@@H](CCCCN)C(=O)O
InChI: InChI=1S/C33H65N5O7S/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-22-30(39)36-27(20-16-18-24-34)31(40)37-28(23-26-46(2,44)45)32(41)38-29(33(42)43)21-17-19-25-35/h27-29H,3-26,34-35H2,1-2H3,(H,36,39)(H,37,40)(H,38,41)(H,42,43)/t27-,28-,29-/m0/s1

Also called

MATRIXYL synthe'6
Palmitoyl Tripeptide-38

Notes unverified prose

Topical cosmetic studies only

Not on file 1

1 of the 8 fields we track hold nothing on this record, and each says why. A blank field is a bug; a named absence is a finding.

amino-acid sequencenothing we hold supplies it

Each field links to every other record missing the same thing. The full ledger holds 521 gaps across 136 records.