Tissue Repair & Regeneration

Pentapeptide-18

Last updated 12 August 2026

Evidence on file1 computational study · 4 citations not yet graded

Strongest sourcePentapeptide-18 as an anti-aging candidate: Spectroscopic characterization and molecular interaction analysis. (computational study)

Manufacturer’s claim vendor marketing

For a proprietary cosmetic ingredient the manufacturer is the originator — there is no upstream to defer to, and this is often the only description that exists. It is reproduced as an attributed claim, with the label its source gave it. It is not graded and it is not evidence — the graded studies are under Literature.

Vendor claims quoted from fetched page (ci.guide): "it couples to the enkephalin receptor on the outside of the nerve cells, relaxing expression muscles and smoothing wrinkles"; "less effective than Botox injections, but it is safe, has no adverse effects, and preserves facial expressivity"; combined with Argireline it "showed a potentiating effect, yielding more noticeable results". No n= or duration on fetched page.

Manufacturer: Not confirmed on fetched pages (Lipotec/Lubrizol hypothesis not verified; a guessed Lubrizol product URL returned 404)
Sold as: Leuphasyl
Manufacturer’s recommended use: Not specified on fetched page

Source page — nofollow, because a vendor link is a reference here, not an endorsement.

Dosing on file unverified

0.5-5% in serums/creams, 2x/day

Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.

Literature on file 5

computational
Pentapeptide-18 as an anti-aging candidate: Spectroscopic characterization and molecular interaction analysis. graded on: a computational prediction — read from the indexed abstract — “molecular docking”

Not graded

4 citations whose study design could not be read from the title. Left ungraded rather than guessed at.

Identity

Space-filling 3D model of Pentapeptide-18, carbon grey, nitrogen blue, oxygen red — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

2D chemical structure of Pentapeptide-18 — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

Molecular weight: 569.6
Molecular formula: C29H39N5O7
CAS number: 64963-01-5
PubChem CID: 10099522
InChI key: ZHUJMSMQIPIPTF-JMBSJVKXSA-N
SMILES: C[C@H](C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)N
InChI: InChI=1S/C29H39N5O7/c1-17(2)13-24(29(40)41)34-28(39)23(15-19-7-5-4-6-8-19)33-25(36)16-31-26(37)18(3)32-27(38)22(30)14-20-9-11-21(35)12-10-20/h4-12,17-18,22-24,35H,13-16,30H2,1-3H3,(H,31,37)(H,32,38)(H,33,36)(H,34,39)(H,40,41)/t18-,22+,23+,24+/m1/s1

Also called

Leuphasyl
Pentapeptide-18

Notes unverified prose

Clinical trial (n=20, 0.5-2%, 2 months): 2% showed significant wrinkle improvement; 28-day (n=14, 5%): wrinkle depth -11.64%; Clinical trial: 5% reduced wrinkle depth 11.64% at 28 days; 0.5-2% study

Not on file 1

1 of the 8 fields we track hold nothing on this record, and each says why. A blank field is a bug; a named absence is a finding.

amino-acid sequencenothing we hold supplies it

Each field links to every other record missing the same thing. The full ledger holds 521 gaps across 136 records.