PYY3-36: dosing, evidence, sources and gaps

Dosing on file unverified

IV infusion: 0.2-0.8 pmol/kg/min; Intranasal: 20-50 µg; Oral: 0.25-4.0 mg

Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.

Literature on file 3

human observational
NCT02493959: Degradation of the Anorexic Hormone Peptide YY graded on: a registered clinical study — “clinicaltrials.gov”

Not graded

2 citations whose study design could not be read from the title. Left ungraded rather than guessed at.

Identity

Space-filling 3D model of PYY3-36, carbon grey, nitrogen blue, oxygen red — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

2D chemical structure of PYY3-36 — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

Molecular weight: 4050
Molecular formula: C180H278N52O55
PubChem CID: 172966225
InChI key: AOHBOXXHKFELOK-LASSKCETSA-N
SMILES: CC[C@H](C)[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC4=CC=C(C=C4)O)C(=O)N[C@@H](CC5=CC=C(C=C5)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC6=CNC=N6)C(=O)N[C@@H](CC7=CC=C(C=C7)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC8=CC=C(C=C8)O)C(=O)O)N
InChI: InChI=1S/C180H278N52O55/c1-17-91(12)141(185)170(280)213-114(27-18-19-61-181)174(284)231-67-25-33-130(231)168(278)210-111(53-58-137(246)247)146(256)203-94(15)173(283)230-66-24-32-129(230)167(277)199-82-135(243)204-109(52-57-136(244)245)151(261)224-125(80-140(252)253)156(266)202-93(14)145(255)227-128(84-234)175(285)232-68-26-34-131(232)169(279)211-113(55-60-139(250)251)153(263)209-112(54-59-138(248)249)154(264)214-116(70-87(4)5)158(268)222-123(78-133(183)241)163(273)207-105(28-20-62-195-177(186)187)148(258)218-120(74-97-37-45-102(237)46-38-97)161(271)219-119(73-96-35-43-101(236)44-36-96)155(265)201-92(13)144(254)226-127(83-233)166(276)217-115(69-86(2)3)157(267)206-106(29-21-63-196-178(188)189)149(259)221-122(77-100-81-194-85-200-100)162(272)220-121(75-98-39-47-103(238)48-40-98)160(270)215-117(71-88(6)7)159(269)223-124(79-134(184)242)164(274)216-118(72-89(8)9)165(275)228-142(90(10)11)171(281)229-143(95(16)235)172(282)212-108(31-23-65-198-180(192)193)147(257)208-110(51-56-132(182)240)152(262)205-107(30-22-64-197-179(190)191)150(260)225-126(176(286)287)76-99-41-49-104(239)50-42-99/h35-50,81,85-95,105-131,141-143,233-239H,17-34,51-80,82-84,181,185H2,1-16H3,(H2,182,240)(H2,183,241)(H2,184,242)(H,194,200)(H,199,277)(H,201,265)(H,202,266)(H,203,256)(H,204,243)(H,205,262)(H,206,267)(H,207,273)(H,208,257)(H,209,263)(H,210,278)(H,211,279)(H,212,282)(H,213,280)(H,214,264)(H,215,270)(H,216,274)(H,217,276)(H,218,258)(H,219,271)(H,220,272)(H,221,259)(H,222,268)(H,223,269)(H,224,261)(H,225,260)(H,226,254)(H,227,255)(H,228,275)(H,229,281)(H,244,245)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,286,287)(H4,186,187,195)(H4,188,189,196)(H4,190,191,197)(H4,192,193,198)/t91-,92-,93-,94-,95+,105-,106-,107-,108-,109-,110-,111-,112+,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,141-,142-,143-/m0/s1

Notes unverified prose

NCT02493959; Human IV infusion studies

Not on file 2

2 of the 8 fields we track hold nothing on this record, and each says why. A blank field is a bug; a named absence is a finding.

CAS registry numbernothing we hold supplies it
amino-acid sequencenothing we hold supplies it

Each field links to every other record missing the same thing. The full ledger holds 521 gaps across 136 records.