Tissue Repair & Regeneration

TB-500

A soft-tissue repair signal for migration, recovery, and remodeling research.

Last updated 12 August 2026

Studied forSoft-tissue repair · Post-surgical recovery · Anti-inflammatory support

Evidence on file1 randomised human trial · 1 animal study · 5 citations not yet graded

Strongest sourceNCT07487363: A Phase 1/2, Randomized, Double-Blind, Placebo-Controlled, Sequential Dose-Escalation Study of T… (randomised human trial)

Mechanism

Actin-sequestering signal associated with cell migration and angiogenesis.

Reported effects

What sources associate with this compound. Reported categories, not outcomes we have graded — each would need its own citation and rung.

Soft-tissue repair
Post-surgical recovery
Anti-inflammatory support

Dosing on file unverified

2-4 mg 2x/week, cycled 4–8 weeks

Reported dose	Volume	Draw
Low — 2 mg	0.4 mL	40 units
High — 4 mg	0.8 mL	80 units

What that assumes. Assumes 10 mg in 2 mL (5000 mcg/mL) drawn on a U-100 barrel — the preset on this record, not a recommendation and not the only way to mix it. Change the vial mass, the diluent or the barrel and every number in this table changes. Run your own.

Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.

Reconstitution

Vial	Diluent	Concentration	Typical dose	Draw
10 mg	2 mL	5000 mcg/mL	2000 mcg	40 units

mass ÷ diluent = concentration; dose ÷ concentration = volume; volume × the syringe factor = units on the barrel (100 for U-100, 40 for U-40). Run your own numbers.

Reported adverse effects

No controlled human safety data exists.

Lethargy after initial doses

Anecdotally reportedonset: First dosesreported reversible

Literature on file 7

animal in vivo
Effects of BPC-157 and TB-500 on Achilles tendon healing in rats: A histopathological and biomechanical study. graded on: an animal model — “rats”
human RCT
NCT07487363: A Phase 1/2, Randomized, Double-Blind, Placebo-Controlled, Sequential Dose-Escalation Study of TB-500 (Thymosin Beta 4 17-23 Fragment) in Adults With Stable Atherosclerotic Cardiovascular Disease to Evaluate Safety, Tolerability, Pharmacokinetics, and Exploratory Cardiovascular Biomarkers graded on: randomised and placebo-controlled — “Randomized, Double-Blind, Placebo-Controlled”

Not graded

5 citations whose study design could not be read from the title. Left ungraded rather than guessed at.

Identity

Space-filling 3D model of TB-500, carbon grey, nitrogen blue, oxygen red — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

2D chemical structure of TB-500 — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

Molecular weight: 4963.4408
Molecular formula: C38H68N10O14
CAS number: 885340-08-9
PubChem CID: 62707662
InChI key: ADKDNDYYIZUVCZ-ZQNQAVPYSA-N
Sequence: LKKTETQ
SMILES: C[C@H]([C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)N)C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)C)O
InChI: InChI=1S/C38H68N10O14/c1-19(2)18-27(42-22(5)51)35(58)44-23(10-6-8-16-39)32(55)43-24(11-7-9-17-40)33(56)47-30(20(3)49)36(59)45-25(13-15-29(53)54)34(57)48-31(21(4)50)37(60)46-26(38(61)62)12-14-28(41)52/h19-21,23-27,30-31,49-50H,6-18,39-40H2,1-5H3,(H2,41,52)(H,42,51)(H,43,55)(H,44,58)(H,45,59)(H,46,60)(H,47,56)(H,48,57)(H,53,54)(H,61,62)/t20-,21-,23+,24+,25+,26+,27+,30+,31+/m1/s1

Classified as

Angiogenesis Modulationmechanism: New vessel growth is one of the concrete, measurable steps in the Wound Healing Cascade, so this is where a repair claim can be traced to something specific rather than left as the word healing.
Subcutaneousroute: This is the route the reconstitution arithmetic assumes. Mass divided by diluent volume gives concentration, dose divided by concentration gives volume, and volume in mL multiplied by 100 gives units on a U-100 barrel: 5 mg in 2 mL is 2.5 mg/mL, and 0.25 mg comes out at 0.1 mL, which is 10 units.

Also called

TB-500
TB-500 (Thymosin Beta-4 frag)
TB-500 (Thymosin Beta-4 fragment)

Notes unverified prose

Phase 1 IV safety trial (0.05-25 mcg/kg); no published human TB-500-specific Phase 3; no FDA-approved dose; No published Phase 2/3 trials for injectable use; RGN-259 for dry eye (RegeneRx)

Not on file 0

All 8 tracked fields hold a value on this record: molecular weight and formula, CAS number, PubChem CID, amino-acid sequence, SMILES, InChI and InChI key.

Counted from the record itself, not from what a source said it was missing. 136 of 185 records still have at least one empty.

Listed prices 8

What 8 shops we track listed for TB-500, read from their own public catalogues on 2026-08-12. We take no commission on these and they are not ranked by any payment — how vendors are scored.

Listed in CAD
Vendor	Size	Price	Per mg
PeptideProCanada	10 mg	$65.00 CAD ~~$95.00 CAD~~	$6.50/mg
VPeptide Canada	10 mg	$69.99 CAD	$7.00/mg
Panda Peptide	5 mg	$44.99 CAD	$9.00/mg
Researched Peptides	size not listed	$54.99 CAD	—
Peptide Supply Online	size not listed	$80.00 CAD	—
NCRP Canada	size not listed	$90.00 CAD	—

Listed in USD
Vendor	Size	Price	Per mg
Verified Peptides	10 mg	$62.00 USD	$6.20/mg
ResearchChemical.com	5 mg	$74.99 USD	$15.00/mg

Prices are the vendor's own listing, reproduced with the date we read it — never converted between currencies, and compared per milligram only where the vendor states the vial size.