Cardiovascular & General; Sleep, Mood & Stress / Cardiovascular

Urotensin II

Last updated 12 August 2026

Evidence on file1 human observational study · 3 animal studies · 1 in-vitro study · 3 citations not yet graded

Strongest sourceNCT00163995: Urotensin II and Vascular Tone in Cirrhosis (human observational study)

Dosing on file unverified

No established human therapeutic dose; research infusions only

Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.

Literature on file 8

animal in vivo
Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord (Proceedings of the National Academy of Sciences 1998, cited 339x) graded on: an animal model — “frog”
in vitro
In-vitro effects of the urotensin-II peptide and its receptor antagonists on mcf-7 breast cancer cell line. graded on: an in-vitro system — “cell line”
animal in vivo
EFFECTS OF THE UROTENSIN-II RECEPTOR ANTAGONIST SB-710411 ON REMOTE ISCHEMIC PRECONDITIONING IN A RAT MODEL OF LPS-INDUCED ENDOTOXIC SHOCK: CARDIOVASCULAR RESPONSE, INFLAMMATORY INJURY, AND SURVIVAL. graded on: an animal model — “RAT”
animal in vivo
Involvement of gap junction, calcium and potassium channels in Urotensin II reactivity in diabetic rat isolated aorta. graded on: an animal model — “rat”
human observational
NCT00163995: Urotensin II and Vascular Tone in Cirrhosis graded on: a registered clinical study — “clinicaltrials.gov”

Not graded

3 citations whose study design could not be read from the title. Left ungraded rather than guessed at.

Identity

Space-filling 3D model of Urotensin II, carbon grey, nitrogen blue, oxygen red — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

2D chemical structure of Urotensin II — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

Molecular weight: 1388.6
Molecular formula: C64H85N13O18S2
CAS number: 9047-55-6
PubChem CID: 46225600
InChI key: HFNHAPQMXICKCF-USJMABIRSA-N
SMILES: C[C@H]([C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC2=O)CC3=CC=CC=C3)CC4=CNC5=CC=CC=C54)CCCCN)CC6=CC=C(C=C6)O)C(=O)N[C@@H](C(C)C)C(=O)O)NC(=O)[C@H](CCC(=O)O)N)O
InChI: InChI=1S/C64H85N13O18S2/c1-33(2)52(64(94)95)75-61(91)48-32-97-96-31-47(73-59(89)46(29-51(82)83)72-62(92)49-17-11-25-77(49)63(93)53(34(3)78)76-54(84)40(66)22-23-50(80)81)60(90)70-43(26-35-12-5-4-6-13-35)56(86)71-45(28-37-30-67-41-15-8-7-14-39(37)41)58(88)68-42(16-9-10-24-65)55(85)69-44(57(87)74-48)27-36-18-20-38(79)21-19-36/h4-8,12-15,18-21,30,33-34,40,42-49,52-53,67,78-79H,9-11,16-17,22-29,31-32,65-66H2,1-3H3,(H,68,88)(H,69,85)(H,70,90)(H,71,86)(H,72,92)(H,73,89)(H,74,87)(H,75,91)(H,76,84)(H,80,81)(H,82,83)(H,94,95)/t34-,40+,42+,43+,44+,45+,46+,47+,48+,49+,52+,53+/m1/s1

Notes unverified prose

No FDA approval; preclinical only; no human therapeutic dosing; Phase 1 trials (antagonist); no approved therapeutic; preclinical

Not on file 1

1 of the 8 fields we track hold nothing on this record, and each says why. A blank field is a bug; a named absence is a finding.

amino-acid sequencenothing we hold supplies it

Each field links to every other record missing the same thing. The full ledger holds 521 gaps across 136 records.