Tissue Repair & Regeneration

ARA-290

A tissue-protective signal studied for nerve irritation and repair.

Last updated 12 August 2026

Studied forNeuropathic discomfort support · Nerve recovery · Sleep quality

Evidence on file1 randomised human trial · 1 human observational study · 1 animal study · 4 citations not yet graded

Strongest sourceNCT06626971: A Phase II Clinical Trial on the Use of ARA 290 for the Treatment of Diabetic Macular Oedema (randomised human trial)

Mechanism

Activates innate repair receptor signaling and tissue-protective pathways.

Reported effects

What sources associate with this compound. Reported categories, not outcomes we have graded — each would need its own citation and rung.

Neuropathic discomfort support
Nerve recovery
Sleep quality

Dosing on file unverified

4 mg daily, cycled 4–12 weeks

Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.

Reconstitution

Vial	Diluent	Concentration	Typical dose	Draw
10 mg	2 mL	5000 mcg/mL	4000 mcg	80 units

mass ÷ diluent = concentration; dose ÷ concentration = volume; volume × the syringe factor = units on the barrel (100 for U-100, 40 for U-40). Run your own numbers.

Literature on file 7

animal in vivo
Immunometabolic dysregulation drives selective executive cognitive dysfunction in male db/db mice. graded on: an animal model — “mice”
human observational
NCT02070783: The Effects of ARA290 on the Cognitive and Neural Processing of Emotions in Healthy Volunteers graded on: a registered clinical study — “clinicaltrials.gov”
human RCT
NCT06626971: A Phase II Clinical Trial on the Use of ARA 290 for the Treatment of Diabetic Macular Oedema graded on: a phase 2 trial — “Phase II Clinical Trial”

Not graded

4 citations whose study design could not be read from the title. Left ungraded rather than guessed at.

Identity

Space-filling 3D model of ARA-290, carbon grey, nitrogen blue, oxygen red — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

2D chemical structure of ARA-290 — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

Molecular weight: 1257.3
Molecular formula: C51H84N16O21
CAS number: 1208243-50-8
PubChem CID: 91810664
InChI key: WZTIQQBMSJTRBR-WYKNNRPVSA-N
Sequence: XEQLERALNSS
SMILES: C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCC(=O)N1
InChI: InChI=1S/C51H84N16O21/c1-22(2)17-30(47(84)65-32(19-36(53)71)48(85)66-33(20-68)49(86)67-34(21-69)50(87)88)63-40(77)24(5)57-41(78)25(7-6-16-56-51(54)55)59-43(80)29(11-15-39(75)76)62-46(83)31(18-23(3)4)64-45(82)27(8-12-35(52)70)60-44(81)28(10-14-38(73)74)61-42(79)26-9-13-37(72)58-26/h22-34,68-69H,6-21H2,1-5H3,(H2,52,70)(H2,53,71)(H,57,78)(H,58,72)(H,59,80)(H,60,81)(H,61,79)(H,62,83)(H,63,77)(H,64,82)(H,65,84)(H,66,85)(H,67,86)(H,73,74)(H,75,76)(H,87,88)(H4,54,55,56)/t24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-/m0/s1

Classified as

Innate Repair Receptor Signalingmechanism: It is one of the clearest cases on the site of a mechanism designed to separate a wanted effect from an unwanted one, so records here should be read for whether that separation was demonstrated rather than merely intended.

Also called

ARA-290
Cibinetide
Pglu-glu-gln-leu-glu-arg-ala-leu-asn-ser-ser
Phbsp
cibinetida

Not on file 0

All 8 tracked fields hold a value on this record: molecular weight and formula, CAS number, PubChem CID, amino-acid sequence, SMILES, InChI and InChI key.

Counted from the record itself, not from what a source said it was missing. 136 of 185 records still have at least one empty.