MOTS-c

Mechanism

Associated with AMPK activation and improved metabolic flexibility.

Reported effects

What sources associate with this compound. Reported categories, not outcomes we have graded — each would need its own citation and rung.

• Fat oxidation
• Training tolerance
• Metabolic flexibility

Reconstitution

mass ÷ diluent = concentration; dose ÷ concentration = volume; volume × the syringe factor = units on the barrel (100 for U-100, 40 for U-40). Run your own numbers.

Reported adverse effects

No controlled human safety data exists.

Literature on file 7

• animal in vivo
  Mitochondrial peptide MOTS-c suppresses systemic and cardiac inflammasome activation in a diabetic rat model. graded on: an animal model — “rat”
• human RCT
  NCT07505745: A Phase 2a, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Pharmacodynamics of MOTS-c (a Mitochondrial-Derived Peptide) in Adults With Prediabetes and Overweight/Obesity graded on: a randomised study — “Randomized, Double-blind, Placebo-controlled Study”

Not graded

5 citations whose study design could not be read from the title. Left ungraded rather than guessed at.

• not graded
  MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation (2023, cited 38x)
• not graded
  MOTS-c: How a secreted mitochondrial microprotein may become a potential treatment for inflammatory lung diseases.
• not graded
  MOTS-c partially protects against skeletal muscle deterioration in C26 cachexia.
• not graded
  Mitochondrial-derived peptide MOTS-c activates metabolic signaling but blunts reparative function in human mesenchymal stromal cells.
• not graded
  LAT1-mediated delivery of engineered R13A-MOTS-c attenuates radiation-induced lung injury via Nrf2 activation and mitochondrial protection.

Identity

PubChem CID 146675088 computed 3D conformer

Skeletal formulathe canonical depiction

Drawn by PubChem from CID 146675088, the identifier on this record.

Molecular weight

2174.6

Molecular formula

C101H152N28O22S2

CAS number

1627580-64-6

PubChem CID

146675088

InChI key

WYTHCOXVWRKRAH-LOKRTKBUSA-N

Sequence

MRWQEMGYIFYPRKLR

SMILES

CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCSC)N

InChI

InChI=1S/C101H152N28O22S2/c1-7-57(4)83(96(148)126-76(50-58-19-9-8-10-20-58)92(144)127-78(52-60-30-34-63(131)35-31-60)97(149)129-46-18-27-79(129)95(147)122-69(25-16-44-112-100(107)108)86(138)118-67(23-13-14-42-102)87(139)124-74(49-56(2)3)91(143)123-73(98(150)151)26-17-45-113-101(109)110)128-94(146)75(51-59-28-32-62(130)33-29-59)116-81(133)55-115-85(137)72(41-48-153-6)121-90(142)71(37-39-82(134)135)119-89(141)70(36-38-80(104)132)120-93(145)77(53-61-54-114-66-22-12-11-21-64(61)66)125-88(140)68(24-15-43-111-99(105)106)117-84(136)65(103)40-47-152-5/h8-12,19-22,28-35,54,56-57,65,67-79,83,114,130-131H,7,13-18,23-27,36-53,55,102-103H2,1-6H3,(H2,104,132)(H,115,137)(H,116,133)(H,117,136)(H,118,138)(H,119,141)(H,120,145)(H,121,142)(H,122,147)(H,123,143)(H,124,139)(H,125,140)(H,126,148)(H,127,144)(H,128,146)(H,134,135)(H,150,151)(H4,105,106,111)(H4,107,108,112)(H4,109,110,113)/t57-,65-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,83-/m0/s1

Classified as

AMPK Signalingmechanism

AMPK appears on records from metabolic to longevity because it is a hub rather than a specific target. That breadth is a reason to read the individual claim and its rung rather than the pathway name.

Mitochondrial Functionpathway

The phrase appears in a great deal of product copy but is measured very differently across studies, from oxygen consumption in cultured cells to exercise capacity in a person, and the rung a claim earns usually depends on which was actually done.

Subcutaneousroute

This is the route the reconstitution arithmetic assumes. Mass divided by diluent volume gives concentration, dose divided by concentration gives volume, and volume in mL multiplied by 100 gives units on a U-100 barrel: 5 mg in 2 mL is 2.5 mg/mL, and 0.25 mg comes out at 0.1 mL, which is 10 units.

Also called

• MOTS-c
• MOTS-c (Longevity)

Listed prices 33

What 33 shops we track listed for MOTS-c, read from their own public catalogues on 2026-08-12. We take no commission on these and they are not ranked by any payment — how vendors are scored.

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