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Dosing and scheduling

Co-administration

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Taking two or more compounds close enough together that they are present in the body at the same time. The term is neutral: it records the fact of overlap and says nothing about whether that combination has been studied. Trials use the word when a pairing has been deliberately tested together.

Why it matters here

Overlap is where interactions happen, and an interaction can run either way, with one compound raising, lowering or hiding the effect of another. Whether a pairing has been tested together is a different question from whether each has been tested alone, and the second does not answer the first.

What it is not

Co-administration is not mixing two compounds in one syringe. Being present in the body together is a biological question, while sharing a barrel is a chemistry and sterility question, and two compounds can be perfectly compatible in the body yet ruin each other in a syringe.

Also called

Concomitant use is the clinical phrasing you will meet in papers and safety reports. On forums the same idea is usually written as running them together.

Compounds carrying this term

None on file yet. This term is in the controlled vocabulary but no compound record currently uses it — which is a statement about our coverage, not about the term.

See also