Mechanism of Action
NAD+ Metabolism
Last updated
NAD+, nicotinamide adenine dinucleotide, is a coenzyme every cell uses to move electrons during energy production. It is also consumed by repair and signalling enzymes such as the sirtuins and PARPs, so supply and demand both matter. This mechanism covers compounds that feed the salvage route recycling NAD+, or that change the rate at which it is used up. Tissue NAD+ falls with age in several measured models, which is the usual starting point for the literature here.
Why it matters here
Records under this heading tend to pair a well-measured biochemical fact with a much weaker human claim, so the rung on each individual row matters more than the strength of the underlying biochemistry.
What it is not
Raising a precursor is not raising NAD+ in the tissue you care about, and raising tissue NAD+ is not changing anything a person would notice. The alias methylation shift points at a side question, since some precursors consume methyl groups, and is not another name for NAD+ itself.
Also called
- nad+
- nad metabolism
- nad+ pathway
- nicotinamide adenine dinucleotide metabolism
- nad+ salvage
- methylation shift
- nad+ precursor
- nad salvage pathway
- methylation/nad metabolism
NAD+ is nicotinamide adenine dinucleotide, and the plus sign marks the oxidised form rather than an additive. NAD+ salvage is the recycling route rather than fresh synthesis, and NAD+ precursor names an input to that route, not the coenzyme.
Compounds carrying this term
None on file yet. This term is in the controlled vocabulary but no compound record currently uses it — which is a statement about our coverage, not about the term.