Sleep, Mood & Stress; Cognitive & Neuroprotection

Selank

An anxiolytic peptide signal for stress-resilience research.

Last updated 12 August 2026

Studied forAnxiety reduction · Stress resilience · Mood support

Evidence on file1 animal study · 4 citations not yet graded

Strongest sourceSelank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats. (animal study)

Mechanism

Tuftsin analog associated with GABAergic modulation and anti-inflammatory effects.

Reported effects

What sources associate with this compound. Reported categories, not outcomes we have graded — each would need its own citation and rung.

Anxiety reduction
Stress resilience
Mood support

Dosing on file unverified

250-500 mcg daily, cycled 2–4 weeks

Reported dose	Volume	Draw
Low — 250 mcg	0.25 mL	25 units
High — 500 mcg	0.5 mL	50 units

What that assumes. Assumes 2 mg in 2 mL (1000 mcg/mL) drawn on a U-100 barrel — the preset on this record, not a recommendation and not the only way to mix it. Change the vial mass, the diluent or the barrel and every number in this table changes. Run your own.

Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.

Reconstitution

Vial	Diluent	Concentration	Typical dose	Draw
2 mg	2 mL	1000 mcg/mL	250 mcg	25 units

mass ÷ diluent = concentration; dose ÷ concentration = volume; volume × the syringe factor = units on the barrel (100 for U-100, 40 for U-40). Run your own numbers.

Reported adverse effects

Limited safety data outside Russian clinical use

N/Aonset: N/Areversibility not on file

Literature on file 5

animal in vivo
Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats. graded on: an animal model — “Rats”

Not graded

4 citations whose study design could not be read from the title. Left ungraded rather than guessed at.

Identity

Space-filling 3D model of Selank, carbon grey, nitrogen blue, oxygen red — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

2D chemical structure of Selank — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

Molecular weight: 751.9
Molecular formula: C33H57N11O9
CAS number: 129954-34-3
PubChem CID: 11765600
InChI key: JTDTXGMXNXBGBZ-YVHUGQOKSA-N
Sequence: TKPRPGP
SMILES: C[C@H]([C@@H](C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N2CCC[C@H]2C(=O)NCC(=O)N3CCC[C@H]3C(=O)O)N)O
InChI: InChI=1S/C33H57N11O9/c1-19(45)26(35)29(49)41-20(8-2-3-13-34)30(50)44-17-6-11-23(44)28(48)40-21(9-4-14-38-33(36)37)31(51)43-16-5-10-22(43)27(47)39-18-25(46)42-15-7-12-24(42)32(52)53/h19-24,26,45H,2-18,34-35H2,1H3,(H,39,47)(H,40,48)(H,41,49)(H,52,53)(H4,36,37,38)/t19-,20+,21+,22+,23+,24+,26+/m1/s1

Classified as

GABAergic Modulationmechanism: This is where calming and anxiety-related records point, so it is worth checking whether a record rests on a measured receptor action or on an animal behaviour test with a mechanism attached afterwards.
Subcutaneousroute: This is the route the reconstitution arithmetic assumes. Mass divided by diluent volume gives concentration, dose divided by concentration gives volume, and volume in mL multiplied by 100 gives units on a U-100 barrel: 5 mg in 2 mL is 2.5 mg/mL, and 0.25 mg comes out at 0.1 mL, which is 10 units.
Intranasalroute: A nasal device delivers a fixed volume per spray, so concentration rather than syringe volume sets the amount per spray, and a mass figure on a record is not usable until you know how many actuations it was divided across.

Also called

Selank
Selank (Mood)

Notes unverified prose

Approved in Russia as anxiolytic; Russian registration used 400-900 mcg/day; 2,700 mcg/day in GAD study; Approved in Russia; GAD: 2,700 mcg/day

Not on file 0

All 8 tracked fields hold a value on this record: molecular weight and formula, CAS number, PubChem CID, amino-acid sequence, SMILES, InChI and InChI key.

Counted from the record itself, not from what a source said it was missing. 136 of 185 records still have at least one empty.

Listed prices 1

What 1 shop we track listed for Selank, read from their own public catalogues on 2026-08-12. We take no commission on these and they are not ranked by any payment — how vendors are scored.

Listed in CAD
Vendor	Size	Price	Per mg
Peptide Supply Online	size not listed	$38.00 CAD	—

Prices are the vendor's own listing, reproduced with the date we read it — never converted between currencies, and compared per milligram only where the vendor states the vial size.

At a glance

Strongest rung: animal in vivo
Citations: 5
Regulatory: Approved outside the US (source claim, unverified)
Route: Intranasal / Subcutaneous, Intranasal
Declared gaps: 0

Citations by rung

animal in vivo1

Strongest wins, never an average.